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Robitaille, Julie

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Robitaille

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Julie

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Université Laval. Institut sur la nutrition et les aliments fonctionnels

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Voici les éléments 1 - 10 sur 23
  • PublicationRestreint
    The PPAR-gamma P12A polymorphism modulates the relation between dietary fat intake and components of the metabolic syndrome : results from the Quebec Family Study
    (Blackwell-synergy, 2003-03-10) Pérusse, Louis; Vohl, Marie-Claude; Després, Jean-Pierre; Robitaille, Julie
    The metabolic syndrome is a complex disorder characterized by an atherogenic dyslipidemia resulting from the interaction between genetic and nutritional factors. The objective of this study was to examine in a cohort of 720 adults participating in the Québec Family Study (QFS) whether dietary fat interacts with the P12A polymorphism in the gene encoding the peroxisome proliferator‐activated receptor‐gamma (PPAR‐γ), a nuclear factor that regulates lipid and glucose homeostasis. Carriers of the A12 allele had a higher body mass index (BMI), waist circumference, fat mass as well as subcutaneous adipose tissue and visceral adipose tissue (VAT) areas both assessed by computed tomography than P12/P12 homozygotes. Total fat and saturated fat intakes estimated from a 3‐day food record were significantly correlated with several components of the metabolic syndrome in P12/P12 homozygotes. None of these expected associations were observed among carriers of the A12 allele. Furthermore, in a model including the PPAR‐γ P12A polymorphism, fat intake, age and gender, PPAR‐γ P12A and its interaction with fat intake were associated with BMI and waist circumference. Similar results were obtained when saturated fat intake replaced total fat intake into the model. When the two genotype groups were further classified into quartiles of total fat or saturated fat intake and their characteristics compared, an increase in fat intake was associated with an increase in waist circumference in P12/P12 homozygotes but not in A12 carriers. There was no difference in the waist circumference in carriers of the A12 allele whether the fat or the saturated fat intake was high or low. These results suggest that the PPAR‐γ P12A polymorphism can modulate the association between dietary fat intake and components of the metabolic syndrome.
  • PublicationAccès libre
    Individuals with self-determined motivation for eating have better overall diet quality : Results from the PREDISE study
    (Academic Press, 2021-05-24) Carbonneau, Élise; Pelletier, Luc; Bégin, Catherine; Lamarche, Benoît; Bélanger, Mathieu; Provencher, Véronique; Desroches, Sophie; Robitaille, Julie; Vohl, Marie-Claude; Couillard, Charles; Bouchard, Luigi; Houle, Julie; Langlois, Marie-France; Rabasa-Lhoret, Rémi; Corneau, Louise; Lemieux, Simone; Corneau, Louise
    The study aimed at documenting motivational orientations for the regulation of eating as defined by self-determination theory and their association with sociodemographic characteristics and overall diet quality. As part of the PREDISE study, French-speaking women (n = 550) and men (n = 547), aged 18-65 years, living in the Province of Québec, Canada, completed online validated questionnaires. The Regulation of Eating Behavior Scale, based on the self-determination theory, assessed self-determined and non-self-determined motivation to regulate one's eating behavior. Three web-based 24-h food recalls were completed and used to compute the Canadian Healthy Eating Index 2007 (C-HEI), an indicator of the overall adherence to Canadian guidelines for healthy eating. Multiple linear regressions were performed to assess how regulation styles are associated with the C-HEI. Model 1 included no covariate, model 2 included sociodemographic covariates, and fully adjusted model 3 included as covariates sociodemographic variables as well as variables that were previously associated with diet quality, namely nutrition knowledge and social support for healthy eating. Women (p < 0.0001), older individuals (p = 0.0002), those with a higher education level (p < 0.0001), and non-smokers (p < 0.0001) reported higher self-determined motivation score than their counterparts. Self-determined motivation was positively (model 1: B = 4.67, p < 0.0001; model 2: B = 3.82, p < 0.0001; model 3: B = 3.61, p < 0.0001) and non-self-determined motivation was negatively (model 1: B = -1.62, p = 0.0009; model 2: B = -1.63, p = 0.0006; model 2: B = -1.49, p = 0.0022) associated with C-HEI. The present study suggests that some subgroups of the general adult population show more self-determined motivation for eating, which is associated with a better diet quality independently of individual characteristics and other individual and social determinants of healthy eating. Strategies to help individuals internalize the regulation of eating should be further investigated.
  • PublicationAccès libre
    Risks of nutrigenomics and nutrigenetics? What the scientists say
    (Springer, 2013-11-29) Hurlimann, Thierry; Vohl, Marie-Claude; Menuz, Vincent; Robitaille, Julie; Graham, Janice E.; Godard, Béatrice
    Nutrigenomics and nutrigenetics (hereafter NGx) have stimulated expectations for beneficial applications in public health and individuals. Yet, the potential achievability of such promise is not without socioethical considerations that challenge NGx implementation. This paper focuses on the opinions of NGx researchers about potential risks raised by NGx. The results of an online survey show that these researchers (n = 126) are fairly confident about the potential benefits of NGx, and that most downplay its potential risks. Researchers in this field do not believe that NGx will reconfigure foods as medication or transform the conception of eating into a health hazard. The majority think that NGx will produce no added burden on individuals to get tested or to remain compliant with NGx recommendations, nor that NGx will threaten individual autonomy in daily food choice. The majority of researchers do not think that NGx will lead to discrimination against and/or stigmatization of people who do not comply with NGx dietary recommendations. Despite this optimism among NGx researchers, we suggest that key risk factors raised by the socioethical context in which NGx applications will be implemented need to be considered.
  • PublicationAccès libre
    Social support, but not perceived food environment, is associated with diet quality in French-speaking Canadians from the PREDISE study
    (M D P I AG, 2019-12-12) Carbonneau, Élise; Bélanger, Mathieu; Couillard, Charles; Corneau, Louise; Lamarche, Benoît; Lemieux, Simone; Vohl, Marie-Claude; Bouchard, Luigi; Robitaille, Julie; Pelletier, Luc G.; Desroches, Sophie; Houle, Julie; Bégin, Catherine; Langlois, Marie-France; Provencher, Véronique
    The objectives were to assess whether social support for healthy eating and perceived food environment are associated with diet quality, and to investigate if sociodemographic characteristics moderate these associations. A probability sample of French-speaking adults from the Province of Québec, Canada, was recruited in the context of the PREDISE study. Participants reported their perceptions of supportive and non-supportive actions related to healthy eating from close others at home and outside of home (n = 952), and of the accessibility to healthy foods (n = 1035). The Canadian Healthy Eating Index (C-HEI) was calculated based on three Web-based 24 h food recalls. Multiple linear regression models showed that supportive (B = 1.50 (95% CI 0.46, 2.54)) and non-supportive (B = −3.06 (95% CI −4.94, −1.18)) actions related to healthy eating from close others at home were positively and negatively associated with C-HEI, respectively, whereas actions from close others outside of home were not. The negative association between non-supportive actions occurring at home and C-HEI was stronger among participants with lower (vs. higher) levels of education (p interaction = 0.03). Perceived accessibility to healthy foods was not associated with C-HEI (p > 0.05). These results suggest that the social environment may have a stronger influence on healthy eating than the perceived physical environment. This adds support for healthy eating promotion programs involving entire families, especially for more socioeconomically disadvantaged individuals, whose efforts to eat healthily may be more easily thwarted by non-supportive households
  • PublicationRestreint
    Genes, fat intake and cardiovascular disease risk factors in the Quebec Family Study
    (Wiley, 2012-09-06) Bouchard, Claude; Pérusse, Louis; Vohl, Marie-Claude; Robitaille, Julie
    Objective : The aim of this study was to assess gene‐diet interaction effects on cardiovascular disease (CVD) risk factors (waist circumference, plasma triacylglycerol, high‐density lipoprotein‐cholesterol and fasting glucose concentrations, and diastolic and systolic blood pressure) in the Quebec Family Study cohort. Design : Sixty‐four polymorphisms from 45 candidate genes were studied in 645 subjects. Dietary fat intake was obtained from a 3‐day weighted food record. Results : We observed 18 significant interactions at a p value ≤ 0.01. Among them, the Pro12Ala polymorphism in peroxisome proliferator‐activated receptor γ, alone or in interaction with fat intake, significantly modulated waist circumference (p = 0.0005 for both effects). Additionally, the apolipoprotein E genotype in interaction with fat intake was significantly associated with diastolic and systolic blood pressure (p = 0.01 and p = 0.001, respectively). The ghrelin Leu72Met polymorphism also interacted with dietary fat in its relation to waist circumference and triacylglycerol concentrations (p = 0.0004 and p = 0.005). Discussion : These results suggest that several alleles at candidate genes interact with dietary fat intake to modulate well‐known CVD risk factors. The identification of gene‐diet interaction effects is likely to provide useful information concerning the etiology of CVD.
  • PublicationRestreint
    Features of the metabolic syndrome are modulated by an interaction between the PPAR-delta –87T>C polymorphism and dietary fat in French-Canadians
    (Stockton Press, 2006-09-05) Pérusse, Louis; Gaudet, Daniel; Vohl, Marie-Claude; Robitaille, Julie
    Objective: We verified whether genetic variants in this gene are associated with the MS and whether dietary fatty acids interact with the −87T>C polymorphism. Methods: By direct sequencing, we identified 15 variants in the PPAR-delta gene and analyses were pursued with the −87T>C polymorphism for 340 subjects. Results: Metabolic variables were comparable among each genotype group. The −87T>C polymorphism, fat intake and the interaction accounted, respectively for 2.2, 1.9 and 1.5% of the variance in high-density lipoprotein cholesterol (HDL-C) levels (P<0.05) (age, sex and energy intake were included into the model). The total cholesterol/HDL-C ratio was also modulated by a gene–diet interaction and by the –87T>C polymorphism (P<0.05). No gene–diet interaction effects were observed for other features of the MS. The age- and sex-adjusted odds ratio (OR) of exhibiting three or more features of the MS when carrying the −87C allele was 0.62 (P=0.04) compared to –87T/T. However, in subjects consuming less than 34.4% of energy from fat (median of fat consumption), the OR in carriers of the −87C allele was of 0.42 (P=0.008).
  • PublicationRestreint
    The peroxisome proliferator-activated receptor alpha Leu162Val polymorphism influences the metabolic response to a dietary intervention altering fatty acid proportions in healthy men
    (Oxford University Press, 2005-02-01) Paradis, Ann-Marie; Fontaine-Bisson, Bénédicte; Lamarche, Benoît; Lemieux, Simone; Bossé, Yohan; Vohl, Marie-Claude; Couture, Patrick; Robitaille, Julie; Jacques, Hélène; Tchernof, André
    Background : Serum lipid responses to dietary modification are partly determined by genetic factors. Objective : We tested whether plasma lipoprotein and lipid responsiveness to a modification in the dietary ratio of polyunsaturated to saturated fatty acids (P:S) is influenced by the peroxisome proliferator-activated receptor α (PPARα) Leu162Val polymorphism in healthy men. Design : Ten carriers of the V162 allele and 10 L162 homozygotes were matched according to age and body mass index (BMI). During the protocol, all subjects followed the National Cholesterol Education Program Step I diet, but intake of saturated and polyunsaturated fatty acids was adjusted to obtain a P:S of 0.3 for the first 4-wk period (low-P:S diet) and a P:S of 1.0 for the next 4-wk period (high-P:S diet). Results : At screening, the PPARα Leu162Val polymorphism was not associated with anthropometric indexes or plasma lipoprotein and lipid concentrations. After the high-P:S diet, a significant gene-by-diet interaction was observed for changes in plasma total cholesterol, apolipoprotein (apo) A-I, and cholesterol concentrations in small LDL particles (P ≤ 0.05). Mean differences after the high-P:S diet were observed between genotype groups for plasma apo A-I concentrations (P < 0.05). Changes in BMI, waist circumference, and concentrations of triacylglycerol, phospholipid, and apo B did not differ significantly between groups. Conclusion : The PPARα Leu162Val polymorphism may contribute to interindividual variability in plasma lipoprotein and lipid response after modification of the dietary P:S ratio.
  • PublicationAccès libre
    Social support for healthy eating : development and validation of a questionnaire for the French-Canadian population
    (CAB International, 2018-05-28) Carbonneau, Élise; Corneau, Louise; Bradette-Laplante, Maude; Lamarche, Benoît; Lemieux, Simone; Vohl, Marie-Claude; Robitaille, Julie; Desroches, Sophie; Bégin, Catherine; Provencher, Véronique
    Objective: The present study aimed to develop and validate a questionnaire assessing social support for healthy eating in a French-Canadian population. Design: A twenty-one-item questionnaire was developed. For each item, participants were asked to rate the frequency, in the past month, with which the actions described had been done by family and friends in two different environments: (i) at home and (ii) outside of home. The content was evaluated by an expert panel. A validation study sample was recruited and completed the questionnaire twice. Exploratory factor analysis was performed on items to assess the number of subscales. Internal consistency reliability was assessed using Cronbach's ɑ. Test-retest reliability was evaluated with intraclass correlations between scores of the two completions. Setting: Online survey. Subjects: Men and women from the Québec City area (n 150). Results: The content validity assessment led to a few changes, resulting in a twenty-two-item questionnaire. Exploratory factor analysis revealed a two-factor structure for both environments, resulting in four subscales: supportive actions at home; non-supportive actions at home; supportive actions outside of home; and non-supportive actions outside of home. Two items were removed from the questionnaire due to low loadings. The four subscales were found to be reliable (Cronbach's ɑ=0·82-0·94; test-retest intraclass correlation=0·51-0·70). Conclusions: The Social Support for Healthy Eating Questionnaire was developed for a French-Canadian population and demonstrated good psychometric properties. This questionnaire will be useful to explore the role of social support and its interactions with other factors in predicting eating behaviours.
  • PublicationAccès libre
    Current knowledge and interest of French Canadians regarding nutrigenetics
    (New Century Health Publishers LLC, 2019-02-19) Vallée-Marcotte, Bastien; Cormier, Hubert; Garneau, Véronique; Vohl, Marie-Claude; Robitaille, Julie; Desroches, Sophie
    Objective: The purpose of this study was to draw a global portrait of the current knowledge and interest regarding nutrigenetics in a population of French Canadians from the province of Quebec (Canada). Methods: A total of 2238 residents from the province of Quebec, Canada, were recruited via social networks and from the Laval University employees/students lists to participate to a 37-question online survey on nutrigenetics. Results: Most participants were not familiar with the term “nutrigenetics” (82.7%). Participants with good genetic literacy (26.8%) were less interested in nutrigenetic testing (p<0.0001). The vast majority of participants (90.7%) reported to be willing to follow a personalized diet based on nutrigenetic testing, especially if they came to know themselves as carriers of a polymorphism increasing the risk of certain diseases. Participants had higher interest in testing related to metabolic response to macronutrients (types of sugars, fats and proteins) than to micronutrients or other nutrients related to food intolerance. Conclusions: The attitude of French Canadians about nutrigenetics are very consistent with results from other survey published in the literature. Although few individuals are familiar with nutrigenetics, public’s attitude towards nutrigenetics is globally favourable.
  • PublicationAccès libre
    Social support for healthy eating : development and validation of a questionnaire for the French-Canadian population
    (CAB International, 2018-05-28) Carbonneau, Élise; Corneau, Louise; Bradette-Laplante, Maude; Lamarche, Benoît; Lemieux, Simone; Vohl, Marie-Claude; Robitaille, Julie; Desroches, Sophie; Bégin, Catherine; Provencher, Véronique
    Objective: The present study aimed to develop and validate a questionnaire assessing social support for healthy eating in a French-Canadian population. Design: A twenty-one-item questionnaire was developed. For each item, participants were asked to rate the frequency, in the past month, with which the actions described had been done by family and friends in two different environments: (i) at home and (ii) outside of home. The content was evaluated by an expert panel. A validation study sample was recruited and completed the questionnaire twice. Exploratory factor analysis was performed on items to assess the number of subscales. Internal consistency reliability was assessed using Cronbach’s ɑ. Test–retest reliability was evaluated with intraclass correlations between scores of the two completions. Setting: Online survey. Subjects: Men and women from the Québec City area (n 150). Results: The content validity assessment led to a few changes, resulting in a twenty-two-item questionnaire. Exploratory factor analysis revealed a two-factor structure for both environments, resulting in four subscales: supportive actions at home; non-supportive actions at home; supportive actions outside of home; and non-supportive actions outside of home. Two items were removed from the questionnaire due to low loadings. The four subscales were found to be reliable (Cronbach’s ɑ=0·82–0·94; test–retest intraclass correlation=0·51–0·70). Conclusions: The Social Support for Healthy Eating Questionnaire was developed for a French-Canadian population and demonstrated good psychometric properties. This questionnaire will be useful to explore the role of social support and its interactions with other factors in predicting eating behaviours.