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Personne :
Marc-Sériès, Isabelle

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Marc-Sériès

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Isabelle

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Université Laval. Département de pédiatrie

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ncf10327615

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Voici les éléments 1 - 4 sur 4
  • PublicationAccès libre
    Postnatal prevention of childhood obesity in offspring prenatally exposed to gestational diabetes mellitus : where are we now?
    (S. Karger, 2017-08-23) Perron, Julie; Mercier, Roxanne; Weisnagel, John; Kearney, Michèle; Marc-Sériès, Isabelle; Robitaille, Julie; Tchernof, André; Dugas, Camille
    Children exposed to gestational diabetes mellitus (GDM) in utero are at high risk of developing many health problems such as obesity. There is an urgent need to find new strategies to prevent obesity development among high-risk populations such as those children. Accordingly, the aim of this review was to summarize current knowledge on the postnatal prevention of childhood obesity in offspring born from mothers with GDM. Specifically, this review addresses the impact of breastfeeding, complementary feeding practices as well as dietary intake and physical activity during childhood on obesity risk of children exposed to GDM in utero. Furthermore, breast milk composition of diabetic mothers and its potential impact on growth is discussed. According to the available literature, breastfeeding may reduce obesity risk in children exposed to GDM in utero but a longer duration seems necessary to achieve its protective effect against obesity. Detailed analysis of breast milk composition of mothers with GDM will be necessary to fully understand the relationship between breastfeeding and obesity in this specific population. This review highlights the need for more studies addressing the impact of complementary feeding practices and lifestyle habits during childhood on obesity risk of children exposed to GDM in utero.
  • PublicationAccès libre
    Bénéfices d'une analgésie non pharmacologique par l'hypnose dans la prise en charge de la douleur aiguë et de l'anxiété des femmes lors de l'interruption de grossesse du premier trimestre
    (2007) Marc-Sériès, Isabelle; Dodin-Dewailly, Sylvie; Verreault, René
    L'exploration de nouvelles démarches dans la prise en charge de la douleur est requise pour intégrer raisonnablement aux soins de haute qualité, des soins plus individualisés. Parmi ces méthodes, l'analgésie hypnotique est une procédure éprouvée expérimentalement par laquelle des suggestions appropriées d'analgésie hypnotique modifient les réponses physiologiques associées à la douleur au niveau périphérique (e.g. réponses autonomiques) et central (spinal et cérébral) et atténuent les réponses nociceptives physiologiques et l'expérience subjective correspondante de la douleur. Lors de l'interruption de grossesse du 1er trimestre (IG), en plus de l'anesthésie du col de l'utérus, divers moyens pharmacologiques sont utilisés avec un succès mitigé pour soulager la douleur et l'anxiété et sont parfois responsables d'effets secondaires (fentanyl, protoxyde d'azote). Chez 30 femmes demandant une IG, notre étude pilote suggère qu'une courte intervention d'hypnose avant et pendant l'IG diminue significativement la consommation de protoxyde d'azote pendant l'IG comparativement aux soins standard (36 % versus 87 %). Suite à cette étude pilote, notre objectif était d'évaluer si, en association avec les soins standards, une intervention brève d'hypnose, avant et pendant la procédure chirurgicale d'IG diminue la consommation de médication analgésique par les femmes lors de l'IG sans toutefois augmenter leur douleur et anxiété lors du geste le plus douloureux de la procédure chirurgicale (soit pendant l'aspiration-évacuation du foetus). Nous avons mené un essai clinique randomisé (n=350) sur une période de un an et demi qui a confirmé la supériorité globale du traitement par l'hypnose par rapport au traitement standard quant à la consommation de médicaments. En effet, dans cette étude, l'intervention standardisée d'hypnose a permis de diminuer le besoin des femmes en sédation par fentanyl et midazolam de plus de 20 % tout en assurant la non-infériorité de l'hypnose par rapport au traitement standard en ce qui concerne les niveaux d'anxiété et de douleur lors de l'aspiration. Nous concluons que l'analgésie hypnotique est une intervention qui peut aider à soulager la douleur et l'anxiété lors d'une IG et plus généralement lors de procédures médicales pour lesquelles douleur et anxiété sont anticipées.
  • PublicationAccès libre
    Association of prenatal exposure to gestational diabetes with offspring body composition and regional body fat distribution
    (Wiley-Blackwell, 2017-12-13) Perron, Julie; Weisnagel, John; Kearney, Michèle; Marc-Sériès, Isabelle; Robitaille, Julie; Tchernof, André
    The aim of this cohort study was to compare body composition and regional body fat distribution between children exposed (GDM+) or unexposed (GDM−) in utero to gestational diabetes mellitus (GDM) and to investigate the association with the glycaemic and the insulin profile. Data from 56 GDM+ and 30 GDM− were analysed. Height, weight and waist circumference were measured. Total and regional body composition was measured by dual-energy X-ray absorptiometry. Insulin, glucose and HbA1c were obtained from a fasting plasma sample, and the HOMA-IR index was calculated. anova was performed to compare adiposity measures between GDM+ and GDM−. Associations between the glycaemic and insulin profile and adiposity measures were studied using partial Pearson correlations. Mean age was 6.6 ± 2.3 years. Waist circumference, fat mass percentage, android fat mass, android fat mass percentage and android-to-gynoid fat mass ratio were higher among GDM+, and lean mass percentage was lower (P < 0.05). Among GDM+ children, body mass index (BMI) z score, waist circumference, fat mass percentage, android fat mass percentage and android-to-gynoid fat mass ratio were all positively correlated with HbA1C (r = 0.32–0.43, P < 0.05). Prenatal exposure to GDM is associated with increased total and abdominal adiposity. This increased adiposity observed among GDM+ children is associated with an altered glycaemic profile. This study is registered in the Clinical Trials.gov registry (NCT01340924). What is already known about this subject? • Although body mass index (BMI) is frequently used to assess children adiposity, other anthropometric measures may be better indicators of cardiometabolic risk. • Few studies investigated others adiposity measures in children exposed to gestational diabetes. What this study adds? • In the current study, adiposity of children exposed to gestational diabetes is evaluated in a more complete and precise manner with assessment of body composition and fat distribution by dual-energy X-ray absorptiometry. • This study also investigates the association of those adiposity measures with children glycaemic and insulin profile.
  • PublicationRestreint
    High-flavanol and high-theobromine versus low-flavanol and low-theobromine chocolate to improve uterine artery pulsatility index: a double blind randomized clinical trial
    (Wiley-Liss, 2016-10-03) Bujold, Emmanuel; Leblanc, Vicky; Lavoie-Lebel, Élise; Anassour-Laouan Sidi, Elhadji; Abdous, Belkacem; Girard, Mario.; Babar, Asma; Poungui, Lionel; Lemieux, Simone; Blanchet, Claudine; Marc-Sériès, Isabelle; Dodin-Dewailly, Sylvie
    Objective: To evaluate the impact of high-flavanol and high-theobromine (HFHT) chocolate in women at risk of preeclampsia (PE). Study design: We conducted a single-center randomized controlled trial including women with singleton pregnancy between 11 and 14 weeks gestation who had bilateral abnormal uterine artery (UtA) waveforms (notching) and elevated pulsatility index (PI). Participants were randomized to either HFHT or low-flavanol and low-theobromine (LFLT) chocolate (30 grams daily for a total of 12 weeks). UtA PI, reported as multiple of medians (MoM) adjusted for gestational age, was assessed at baseline and 12 weeks after randomization. Results: One hundred thirty-one women were randomized with mean gestational age of 12.4 ± 0.6 weeks and a mean UtA PI of 1.39 ± 0.31 MoM. UtA PI adjusted for gestational age significantly decreased from baseline to the second visit (12 weeks later) in the two groups (p < 0.0001) but no significant difference was observed between the groups (p = 0.16). Conclusions: Compared with LFLT chocolate, daily intake of HFHT chocolate was not associated with significant changes of UtA PI. Nevertheless, the improvement observed in both groups suggests that chocolate could improve placental function independently of flavanol and/or theobromine content.