Pour savoir comment effectuer et gérer un dépôt de document, consultez le « Guide abrégé – Dépôt de documents » sur le site Web de la Bibliothèque. Pour toute question, écrivez à corpus@ulaval.ca.
 

Personne :
Muckle, Gina

En cours de chargement...
Photo de profil

Adresse électronique

Date de naissance

Projets de recherche

Structures organisationnelles

Fonction

Nom de famille

Muckle

Prénom

Gina

Affiliation

Université Laval. École de psychologie

ISNI

ORCID

Identifiant Canadiana

ncf10371144

person.page.name

Résultats de recherche

Voici les éléments 1 - 10 sur 18
  • PublicationRestreint
    Language barriers in mental health care : a survey of primary care practitioners
    (Springer Nature, 2013-12-29) Brisset, Camille; Leanza, Yvan; Rosenberg, Ellen; Muckle, Gina; Vissandjée, Bilkis; Kirmayer, Laurence J.; Xenocostas, Spyridoula; Laforce, Hugues
    Many migrants do not speak the official language of their host country. This linguistic gap has been found to be an important contributor to disparities in access to services and health outcomes. This study examined primary care mental health practitioners’ experiences with linguistic diversity. 113 practitioners in Montreal completed a self-report survey assessing their experiences working with allophones. About 40 % of practitioners frequently encountered difficulties working in mental health with allophone clients. Few resources were available, and calling on an interpreter was the most common practice. Interpreters were expected to play many roles, which went beyond basic language translation. There is a clear need for training of practitioners on how to work with different types of interpreters. Training should highlight the benefits and limitations of the different roles that interpreters can play in health care delivery and the differences in communication dynamics with each role.
  • PublicationAccès libre
    Prenatal exposure to polybrominated diphenyl ethers and predisposition to frustration at 7 months : results from the MIREC Study
    (Pergamon, 2018-06-22) Tremblay, Émilie; Boivin, Michel; Arbuckle, Tye Elaine; Ouellet, Emmanuel.; Fraser, William Donald; Forget-Dubois, Nadine; Lemelin, Jean-Pascal; Séguin, Jean R.; Oulhote, Youssef; Ayotte, Pierre; Muckle, Gina; Dionne, Ginette; Lanphear, Bruce P.
    Background: Prenatal exposure to polybrominated diphenyl ethers (PBDEs) has been associated with cognitivedeficits and behavioral problems in children. To date, no study has examined this exposure in association withneurobehavioral development in infants younger than 12 months assessed with observational tasks. Objectives: This study examined the relation between prenatal PBDE concentrations and predisposition tofrustration, assessed by the arm restraint task (ART), in Canadian infants. Methods: In a prospective longitudinal study conducted in Canada, exposure to nine PBDE congeners wasmeasured in maternal plasma during the first trimester of pregnancy. The ART was used to measure predis-position to frustration in infancy (N = 333; mean age = 6.9 months), as assessed by negative vocalizations(crying and screaming) and physical reactivity (discomfort movements). Results: Maternal plasma PBDE-47 concentrations collected during pregnancy were associated with negativevocalizations using the ART (adjusted Relative Risk [aRR] = 1.04, 95% CI: 1.00, 1.09). Prenatal PBDE-99concentrations during pregnancy were also related to a shift to the left in the tail of the distribution of onset ofnegative vocalizations as measured by a decrease of 38 s (95% CI: −78.1, 1.3) in the 75th quantile of thedistribution for infants whose mothers had detectable levels of PBDE-99 compared to infants of mothers withundetectable levels. Similarly, infants whose mothers had detectable levels of PBDE-100 showed an increase of24.1 s (95% CI: 4.1, 44.1) in the 75th quantile of the distribution of proportion of time in negative vocalizationscompared with infants of mothers with undetectable levels. Finally, the association between PBDE-47 and PBDE-153, and physical reactivity was significantly modified by sex (p < 0.1), with opposite patterns in girls andboys. Conclusions: Prenatal exposure to PBDEs was associated with increased incidence of crying and screaming withdelayed onset of discomfort movement, which may indicate a predisposition to frustration and lack of habi-tuation in infants younger than 12 months from the general population.
  • PublicationAccès libre
    Adaptation des mères et des pères à la naissance d'un premier enfant malformé : le rôle du soutien social
    (1993) Muckle, Gina; Tessier, Réjean
    La thèse a deux objectifs: 1) examiner les modalités d'action de dimensions spécifiques du soutien social et 2) étudier la capacité de plusieurs indicateurs de ressources et de stresseurs à dépister dès la période néonatale les nouveaux parents les plus stressés en post-partum. L'adaptation parentale y est aussi étudiée. Il s'agit d'une étude prospective de cohortes appariées, regroupant les mères et pères d'un nouveau-né soit en santé et normalement constitué, soit visiblement malformé. Les sujets sont rencontrés à 1 et 8 mois post-partum. Les analyses de covariance sur les données de 1 mois post-partum montrent que l'action du soutien social sur le bien-être psychologique est fonction de l'exposition et du risque, conformément au modèle théorique de l'effet contextuel du soutien social. De plus, le sentiment d'être soutenu, le soutien émotif provenant du conjoint et la structure du réseau de soutien se distinguent empiriquement et ne sont pas des protecteurs équivalents pour le nouveau parent. Les analyses discriminantes et de classification révèlent que la condition physique du nouveau-né joue un rôle négligeable dans l'identification des mères stressées à 8 mois post-partum. La scolarité, les ressources de soutien et l'appréhension cognitive des stresseurs à la période néonatale permettent d'identifier toutes les mères les plus stressées à 8 mois. Néanmoins, ces variables ne permettent pas d'identifier les pères les plus stressés. L'état de stress des nouveaux parents est également comparé selon le passage du temps, le sexe du parent et le statut de naissance du bébé.
  • PublicationAccès libre
    Prenatal, concurrent, and sex-specific associations between blood lead concentrations and IQ in preschool canadian children
    (2018-11-02) Boivin, Michel; Ouellet, Emmanuel.; Arbuckle, Tye, E.; Forget-Dubois, Nadine; Fraser, William Donald; Desrochers-Couture, Mireille; Séguin, Jean R.; Oulhote, Youssef; Ayotte, Pierre; Muckle, Gina; Lanphear, Bruce P.
    Background Lead exposure predicts altered neurodevelopment and lower intelligence quotient (IQ) in children, but few studies have examined this association in children who have relatively low blood lead concentrations. Objectives To test the associations between blood lead concentrations and cognitive function in Canadian preschoolers, with a possible moderation by sex. Methods The data were gathered from 609 mother-child pairs from the Maternal–Infant Research on Environmental Chemicals (MIREC) Study. Lead was measured in umbilical and maternal blood, and in children's venous blood at age 3–4 years. Cognitive function was measured with the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) at 3–4 years. We tested the relationship between WPPSI-III scores and blood lead concentrations with multiple linear regression, adding child sex as a moderator. Results Median blood lead concentrations for the mother at 1st trimester and 3rd trimester of pregnancy, and for cord and child blood were 0.60 μg/dL, 0.58 μg/dL, 0.79 μg/dL and 0.67 μg/dL, respectively. We found no association between cord blood lead concentrations and WPPSI-III scores in multivariable analyses. However, cord blood lead concentrations showed a negative association with Performance IQ in boys but not in girls (B = 3.44; SE = 1.62; 95% CI: 0.82, 5.98). No associations were found between WPPSI-III scores and prenatal maternal blood or concurrent child blood lead concentrations. Conclusions Prenatal blood lead concentrations below 5 μg/dL were still associated with a decline in cognitive function in this Canadian cohort, but only for boys.
  • PublicationAccès libre
    Seasonal variations in exposure to methylmercury and its dietary sources among pregnant Inuit women in Nunavik, Canada
    (Elsevier, 2020-11-01) De Moraes Pontual, Mariana; Ayotte, Pierre; Little, Matthew; Furgal, Chris; Boyd, Amanda D.; Muckle, Gina; Avard, Ellen; Ricard, Sylvie; Gauthier, Marie-Josée; Anassour-Laouan Sidi, Elhadji; Lemire, Mélanie
    Among populations living in close connection with the sea, rivers and lakes for subsistence, diet varies according to local monthly wildlife species availability and food preferences. This may lead to variations in methylmercury (MeHg) exposure over a year, although no biomonitoring studies have documented this issue in Circumpolar populations, the most exposed to international Hg emissions. Our aim was to characterize seasonal variations in MeHg exposure among pregnant Inuit women from Nunavik and to identify country foods responsible for these variations. Between October 2016 and March 2017, 97 participants were recruited. Blood mercury (Hg) was tested and hair Hg was measured by centimeter as a surrogate for monthly MeHg exposure over the past year. Latent class growth analysis was conducted to identify groups of pregnant women with similar hair Hg monthly trajectories. Country foods consumption was documented by season. Seasonal daily intakes of MeHg were estimated based on concentrations in country foods. Retrospective monthly hair Hg analyses revealed that MeHg exposure was lowest in winter, and highest in summer and early fall months. Three latent classes (groups) of pregnant women with similar trajectories of monthly hair Hg variations were identified: high (n = 20, 21%), moderate (n = 38, 41%) and low variation (n = 35, 38%). Beluga meat was the country food contributing to most of daily MeHg intake, primarily during summer and fall, and was the only one associated with the odds of being classified into moderate and high variation groups (OR 95% CI: 1.19 [1.01–1.39] and 1.25 [1.04–1.50]). These findings underscore the importance of monthly variations in exposure to MeHg due to the seasonality of local foods consumed and responsible for elevated MeHg exposure. Further studies critically need to understand local diet fluctuations over a year to adequately assess MeHg exposure, adopt timely preventive interventions and evaluate the effectiveness of the Minamata Convention.
  • PublicationAccès libre
    Associations of cord blood leptin and adiponectin with children’s cognitive abilities
    (Elsevier Science, 2018-10-25) Li, Nan; Boivin, Michel; Arbuckle, Tye Elaine; Ouellet, Emmanuel.; Muckle, Gina; Lanphear, Bruce P.; Chen, Aimin; Dodds, Linda; Fraser, William Donald; Séguin, Jean R.; Velez, Maria P.; Yolton, Kimberly; Braun, Joseph
    Background : Adipocytokines may play a role in fetal programming of neurodevelopment. We aimed to investigate the associations between cord blood adipocytokine concentrations and children’s intelligence test scores. Methods : We used data from two ongoing pregnancy cohorts in North America: the Maternal-Infant Research on Environmental Chemicals (MIREC, n = 429) and Health Outcomes and Measures of the Environment (HOME, n = 183) Studies. Umbilical cord blood adipocytokine concentrations were measured using enzyme-linked immunosorbent assays. We assessed children’s Intelligence Quotient (IQ) and its components using the Wechsler Preschool and Primary Scales of Intelligence-III or Wechsler Intelligence Scale for Children-IV. We used linear regression and linear mixed models to estimate associations between log2-transformed adipocytokine concentrations and children’s IQ after adjusting for sociodemographic, perinatal, and child factors. Results : After adjusting for covariates, cord blood adiponectin was positively associated with children’s full-scale IQ scores at age 3 years in the MIREC Study (β = 1.4, 95% confidence interval [CI]: 0.2, 2.5) and at ages 5 and 8 years in the HOME Study (β = 1.7, CI: -0.1, 3.5). Adiponectin was positively associated with performance IQ in both studies (MIREC: β = 2.0, CI: 0.7, 3.3; HOME: β = 2.2, CI: 0.5, 3.9). Adiponectin was positively associated with working memory composite scores at age 8 in the HOME Study (β = 3.1, CI: 1.0, 5.2). Leptin was not associated with children’s IQ in either study. Conclusions : Cord blood adiponectin was associated with higher full-scale and performance IQ and working memory composite scores in children. Future studies are needed to explore the mechanisms underlying these associations.
  • PublicationAccès libre
    Perfluoroalkyl acids in pregnant women from Nunavik (Quebec, Canada) : trends in exposure and associations with country foods consumption
    (New York (N.Y.) : Elsevier, 2020-10-17) Caron-Beaudoin, Élyse; Ayotte, Pierre; Blanchette, Caty; Muckle, Gina; Avard, Ellen; Ricard, Sylvie; Lemire, Mélanie
    Objectives From 2004 to 2017, 279 pregnant Inuit women were recruited as part of biomonitoring projects in Nunavik. Our goal was to evaluate: (i) time-trends in plasma/serum PFAAs levels in pregnant Nunavimmiut women between 2004 and 2017; (ii) compare plasma/serum PFAAs levels in Nunavimmiut women in 2016–2017 to those measured in women of childbearing age in the Canadian Health Measure Survey (CHMS); and (iii) evaluate the associations of PFAAs levels with the consumption of country foods and pregnancy and maternal characteristics during pregnancy in the 97 participants recruited in 2016–2017. Methods Individual blood sample were collected for serum or plasma PFAAs (PFOS, PFOA, pentafluorobenzoic acid (PFBA), perfluorohexanoic acid (PFHxA), perfluorobutanesulfonic acid (PFBS), perfluorohexane-1-sulfonic acid (PFHxS), PFNA, PFDA, PFUdA) analyses. Socio-demographic data, pregnancy and maternal characteristics and country foods consumption were documented using a questionnaire. Omega-3 and −6 polyunsaturated fatty acids (PUFA) were measured in red blood cell membranes and their ratio used as a biomarker of marine country foods consumption. Time-trends in PFAAs levels were evaluated using ANCOVA models adjusted for relevant co-variables. Serum/plasma levels of PFAAs in the 97 pregnant women aged 16 to 40 years old and recruited in 2016–2017 were compared to those measured in women aged 18 to 40 years old from the CHMS cycle 5 (2016–2017) using the geometric means (GM) and 95% confidence intervals (95% CI). Multivariate regression analyses were performed to examine associations between concentrations of PFAAs and country foods consumption data. Results Statistically-significant downward time trends were noted for concentrations of PFOS, PFOA and PFHxS in pregnant Nunavik women between 2004 and 2017. Conversely, between 2011 and 2016–2017, PFNA, PFDA and PFUdA maternal serum levels increased by 19, 13 and 21% respectively. Among participants in 2016–2017, mean concentrations for PFNA (GM: 2.4 μg/L), PFDA (0.53 μg/L) and PFUdA (0.61 μg/L) were higher than those measured in women aged 18–40 years old in the Cycle 5 (2016–2017) of the CHMS. PFOA (0.53 μg/L) and PFHxS (0.26 μg/L) were lower than in CHMS, whereas PFBA, PFHxA and PFBS were not detected in 2016–2017. Ratios of serum/plasma levels of PFNA/PFOA, PFNA/PFOS, PFNA/PFHxS and PFUdA/PFDA were significantly higher in the 97 pregnant women from Nunavik recruited in 2016–2017 compared to CHMS, highlighting their distinct exposure profile. In multivariate models, PFHxS, PFOS, PFNA, PFDA and PFUdA levels in 2016–2017 were strongly associated with the omega-3/omega-6 PUFA ratio, indicating a positive association between marine country foods consumption and higher exposure to PFAAs. Conclusions The exposure of pregnant women to long-chain PFAAs (PFNA, PFDA and PFUdA) increased from 2004 to 2017 in Nunavik. Associations noted between PFAAs levels and the omega-3/omega-6 ratio highlights the importance of implementing additional strict regulations on PFAAs and their precursors to protect the high nutritional quality and cultural importance of country foods in Nunavik.
  • PublicationAccès libre
    Local country food sources of methylmercury, selenium and omega-3 fatty acids in Nunavik, Northern Quebec
    (2014-08-15) Lemire, Mélanie; Kwan, Michael K.H.; Anassour-Laouan Sidi, Elhadji; Ayotte, Pierre; Muckle, Gina; Dewailly, Éric; Pirkle, Catherine
    Country foods are central to Inuit culture and replete in selenium (Se) and long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA). However, some marine country foods bioaccumulate high concentrations of methylmercury (MeHg). Se and n-3 are associated with several health benefits in Nunavik, Northern Quebec, but, recent studies show that prenatal MeHg exposure is associated with visual, cognitive and behavioral deficit later in childhood. The study objectives are to identify contemporary country food sources of MeHg, Se and long-chain n-3 PUFA in Nunavik, particularly among childbearing-age women, taking into account regional differences in consumption profiles. The contribution of different country foods to daily MeHg, Se, long-chain n-3 PUFA intake (μg/kg body weight/day) was estimated using: (i) country food consumption and blood biomarkers data from the 2004 Nunavik Health Survey (387 women, 315 men), and (ii) data on MeHg, Se, long-chain n-3 PUFA concentrations found in Nunavik wildlife species. In the region where most traditional beluga hunting takes place in Nunavik, the prevalence of at-risk blood Hg (≥ 8 μg/L) in childbearing-age women was 78.4%. While most country foods presently consumed contain low MeHg, beluga meat, not a staple of the Inuit diet, is the most important contributor to MeHg: up to two-thirds of MeHg intake in the beluga-hunting region (0.66 of MeHg intake) and to about one-third in other regions. In contrast, seal liver and beluga mattaaq - beluga skin and blubber - only mildly contributed to MeHg (between 0.06 and 0.15 of MeHg intake), depending on the region. Beluga mattaaq also highly contributed to Se intake (0.30 of Se intake). Arctic char, beluga blubber and mattaaq, and seal blubber contributed to most long-chain n-3 PUFA intake. This study highlights the importance of considering interconnections between local ecosystems and dietary habits to develop recommendations and interventions promoting country foods' benefits, while minimizing the risk of MeHg from beluga meat, especially for childbearing-age women.
  • PublicationAccès libre
    Altered fine motor function at school age in inuit children exposed to PCBs, methylmercury, and lead
    (Pergamon, 2016-08-27) Boucher, Olivier; Ayotte, Pierre; Muckle, Gina; Dewailly, Éric; Jacobson, Sandra W.; Jacobson, Joseph L.
    Background : Motor deficits have frequently been reported in methylmercury (MeHg) poisoning in adults. However, whether exposure to neurotoxic contaminants from environmental sources early in life is associated with neuromotor impairments has received relatively little attention. This study examines the relation of developmental exposure to MeHg, polychlorinated biphenyls (PCBs), and lead to motor function in school-age Inuit children exposed through their traditional diet. Methods : In a prospective study in Nunavik, children (mean age = 11.3 years) were assessed on a battery of fine motor tasks, namely the Stanford-Binet Copying subtest (N = 262), the Santa Ana Form Board, and the Finger Tapping Test (N = 215). The relation of mercury (Hg; as an index of MeHg exposure), PCB congener 153 (PCB153), and lead concentrations in cord and current blood samples to task performance was examined using linear regression analyses. Results : After adjustment for potential confounders and control for the other contaminants, higher current PCB concentrations were associated with poorer Santa Ana Form Board and Finger Tapping performance. Results were virtually identical when PCB153 was replaced by other PCB congeners. Higher current Hg levels were independently associated with poorer Finger Tapping performance. Conclusions : This is the first prospective longitudinal study in children to provide evidence of neuromotor impairments associated with postnatal exposure to seafood contaminants from environmental sources. Fine motor speed appears particularly sensitive to the effects of postnatal PCB exposure, which is unusually high in this population. Results with postnatal MeHg are concordant with previous cross-sectional studies with children and adults.
  • PublicationAccès libre
    An ERP study of recognition memory for concrete and abstract pictures in school-aged children
    (2016-06-18) Boucher, Olivier; Chouinard-Leclaire, Christine; Muckle, Gina; Westerlund, Alissa; Burden, Matthew J.; Jacobson, Sandra W.; Jacobson, Joseph L.
    Recognition memory for concrete, nameable pictures is typically faster and more accurate than for abstract pictures. A dual-coding account for these findings suggests that concrete pictures are processed into verbal and image codes, whereas abstract pictures are encoded in image codes only. Recognition memory relies on two successive and distinct processes, namely familiarity and recollection. Whether these two processes are similarly or differently affected by stimulus concreteness remains unknown. This study examined the effect of picture concreteness on visual recognition memory processes using event-related potentials (ERPs). In a sample of children involved in a longitudinal study, participants (N=96; mean age=11.3years) were assessed on a continuous visual recognition memory task in which half the pictures were easily nameable, everyday concrete objects, and the other half were three-dimensional abstract, sculpture-like objects. Behavioral performance and ERP correlates of familiarity and recollection (respectively, the FN400 and P600 repetition effects) were measured. Behavioral results indicated faster and more accurate identification of concrete pictures as "new" or "old" (i.e., previously displayed) compared to abstract pictures. ERPs were characterized by a larger repetition effect, on the P600 amplitude, for concrete than for abstract images, suggesting a graded recollection process dependent on the type of material to be recollected. Topographic differences were observed within the FN400 latency interval, especially over anterior-inferior electrodes, with the repetition effect more pronounced and localized over the left hemisphere for concrete stimuli, potentially reflecting different neural processes underlying early processing of verbal/semantic and visual material in memory.