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Ayotte, Pierre

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Ayotte

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Pierre

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Université Laval. Département de médecine sociale et préventive

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ncf10280653

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  • PublicationAccès libre
    MercuNorth - monitoring mercury in pregnant women from the Arctic as a baseline to assess the effectivness of the Minamata Convention
    (Oulu : International Association of Circumpolar Health Publishers, 2021-06-03) Adlard, Bryan; Lemire, Mélanie; Bonefeld-Jørgensen, Eva C.; Long, Manhai; Ólafsdóttir, Kristín; Odland, Jon Øyvind; Rautio, Arja; Myllynen, Päivi; Sandanger, Torkjel M.; Dudarev, Alexey A.; Bergdahl, Ingvar A.; Berner, Jim; Ayotte, Pierre
    Exposure to mercury (Hg) is a global concern, particularly among Arctic populations that rely on the consumption of marine mammals and fish which are the main route of Hg exposure for Arctic populations.The MercuNorth project was created to establish baseline Hg levels across several Arctic regions during the period preceding the Minamata Convention. Blood samples were collected from 669 pregnant women, aged 18–44 years, between 2010 and 2016 from sites across the circumpolar Arctic including Alaska (USA), Nunavik (Canada), Greenland, Iceland, Norway, Sweden, Northern Lapland (Finland) and Murmansk Oblast (Russia). Descriptive statistics were calculated, multiple pairwise comparisons were made between regions, and unadjusted linear trend analyses were performed.Geometric mean concentrations of total Hg were highest in Nunavik (5.20 µg/L) and Greenland (3.79 µg/L), followed by Alaska (2.13 µg/L), with much lower concentrations observed in the other regions (ranged between 0.48 and 1.29 µg/L). In Nunavik, Alaska and Greenland, blood Hg concentrations have decreased significantly since 1992, 2000 and 2010 respectively with % annual decreases of 4.7%, 7.5% and 2.7%, respectively.These circumpolar data combined with fish and marine mammal consumption data can be used for assessing long-term Hg trends and the effectiveness of the Minamata Convention.
  • PublicationAccès libre
    Prenatal exposure to polybrominated diphenyl ethers and predisposition to frustration at 7 months : results from the MIREC Study
    (Pergamon, 2018-06-22) Tremblay, Émilie; Boivin, Michel; Arbuckle, Tye Elaine; Ouellet, Emmanuel.; Fraser, William Donald; Forget-Dubois, Nadine; Lemelin, Jean-Pascal; Séguin, Jean R.; Oulhote, Youssef; Ayotte, Pierre; Muckle, Gina; Dionne, Ginette; Lanphear, Bruce P.
    Background: Prenatal exposure to polybrominated diphenyl ethers (PBDEs) has been associated with cognitivedeficits and behavioral problems in children. To date, no study has examined this exposure in association withneurobehavioral development in infants younger than 12 months assessed with observational tasks. Objectives: This study examined the relation between prenatal PBDE concentrations and predisposition tofrustration, assessed by the arm restraint task (ART), in Canadian infants. Methods: In a prospective longitudinal study conducted in Canada, exposure to nine PBDE congeners wasmeasured in maternal plasma during the first trimester of pregnancy. The ART was used to measure predis-position to frustration in infancy (N = 333; mean age = 6.9 months), as assessed by negative vocalizations(crying and screaming) and physical reactivity (discomfort movements). Results: Maternal plasma PBDE-47 concentrations collected during pregnancy were associated with negativevocalizations using the ART (adjusted Relative Risk [aRR] = 1.04, 95% CI: 1.00, 1.09). Prenatal PBDE-99concentrations during pregnancy were also related to a shift to the left in the tail of the distribution of onset ofnegative vocalizations as measured by a decrease of 38 s (95% CI: −78.1, 1.3) in the 75th quantile of thedistribution for infants whose mothers had detectable levels of PBDE-99 compared to infants of mothers withundetectable levels. Similarly, infants whose mothers had detectable levels of PBDE-100 showed an increase of24.1 s (95% CI: 4.1, 44.1) in the 75th quantile of the distribution of proportion of time in negative vocalizationscompared with infants of mothers with undetectable levels. Finally, the association between PBDE-47 and PBDE-153, and physical reactivity was significantly modified by sex (p < 0.1), with opposite patterns in girls andboys. Conclusions: Prenatal exposure to PBDEs was associated with increased incidence of crying and screaming withdelayed onset of discomfort movement, which may indicate a predisposition to frustration and lack of habi-tuation in infants younger than 12 months from the general population.
  • PublicationAccès libre
    Green Edge ice camp campaigns : understanding the processes controlling the under-ice Arctic phytoplankton spring bloom
    (Göttingen Copernicus Publications, 2020-01-27) Massicotte, Philippe; Amiraux, Rémi; Amyot, Marie-Pier; Archambault, Philippe; Aubry, Cyril; Ayotte, Pierre; Bécu, Guislain; Bélanger, Simon; Bruyant, Flavienne; Christiansen-Stowe, Debra; Coupel, Pierre; Dezutter, Thibaud; Dominé, Florent; Dufour, Francis; Dufresne, Christiane; Dumont, Dany; Ferland, Joannie; Forget, Marie-Hélène; Fortier, Louis; Galí, Martí; Galindo, Virginie; Gourdal, Margaux; Grondin, Pierre-Luc; Guillot, Pascal; Guilmette, Caroline; Lacour, Léo; Lagunas, José Luis; Lalande, Catherine; Laliberté, Julien; Lambert Girard, Simon; Larivière, Jade; Lavaud, Johann; LeBaron, Anita; Lemire, Mélanie; Levasseur, Maurice; Marec, Claudie; Massé, Guillaume; Matsuoka, Atsushi; Neukermans, Griet; Oziel, Laurent; Rehm, Eric Carl; Reimer, Erin; Saint-Béat, Blanche; Sansoulet, Julie; Tremblay, Jean-Éric; Verin, Gauthier; Babin, Marcel
    The Green Edge initiative was developed to investigate the processes controlling the primary productivity and fate of organic matter produced during the Arctic phytoplankton spring bloom (PSB) and to determine its role in the ecosystem. Two field campaigns were conducted in 2015 and 2016 at an ice camp located on landfast sea ice southeast of Qikiqtarjuaq Island in Baffin Bay (67.4797∘ N, 63.7895∘ W). During both expeditions, a large suite of physical, chemical and biological variables was measured beneath a consolidated sea-ice cover from the surface to the bottom (at 360 m depth) to better understand the factors driving the PSB. Key variables, such as conservative temperature, absolute salinity, radiance, irradiance, nutrient concentrations, chlorophyll a concentration, bacteria, phytoplankton and zooplankton abundance and taxonomy, and carbon stocks and fluxes were routinely measured at the ice camp. Meteorological and snow-relevant variables were also monitored. Here, we present the results of a joint effort to tidy and standardize the collected datasets, which will facilitate their reuse in other Arctic studies.
  • PublicationAccès libre
    Non-persistent exposures from plasticizers or plastic constituents in remote Arctic communities : a case for further research
    (New York NY: Nature Pub. Group, 2022-03-28) Aker, Amira; Caron-Beaudoin, Élyse; Ayotte, Pierre; Ricard, Sylvie; Gilbert, Véronique; Avard, Ellen; Lemire, Mélanie
    BACKGROUND: Persistent organic pollutant exposures are well-documented in the Arctic, but fewer studies examined non-persistent chemicals, despite increased market food and consumer product consumption. OBJECTIVE: To measure phenol, paraben, phthalate, and alternative plasticizer concentrations in Inuit adults. METHODS: The study included 30 pooled urine samples from Qanuilirpitaa? 2017 Nunavik Inuit Health Survey (Q2017) participants. Creatinine-adjusted geometric mean concentrations (GM) and 95% confidence intervals (CI) were compared across sex, age, and regions, and compared to those in the Canadian Health Measures Survey (CHMS) and the First Nations Biomonitoring Initiative (FNBI). RESULTS: Q2017 bisphenol-A concentrations were double the CHMS 2018–2019 concentrations [GM (95% CI): 1.98 (1.69–2.31) versus 0.71 (0.60–0.84) µg/g creatinine], but in line with FNBI [1.74 (1.41–2.13) µg/g creatinine]. Several phthalate concentrations were higher in Q2017 versus CHMS, particularly monobenzyl phthalate, which was was 19-fold higher in Q2017 versus CHMS 2018–2019 [45.26 (39.35–52.06) versus 2.4 (2.0–2.9) µg/g creatinine] and four-fold higher than FNBI. There were also four-fold higher concentrations of the two alternate plasticizer 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TIXB) metabolites in Q2017 compared to CHMS 2018–2019. Women and people living in Ungava Bay had generally higher concentrations of non-persistent chemicals. SIGNIFICANCE: The results suggest higher concentrations of certain non-persistent chemicals in Inuit versus the general Canadian population. IMPACT: Few studies have explored non-persistent chemical distributions in Northern communities, despite the increasing consumer product and market food consumption. We analyzed 30 pooled samples from the Qanuilirpitaa? Nunavik Inuit Health Survey 2017 to assess exposures to common plasticizes and plastic constituents and compare their levels with the general Canadian population and First Nation groups. We observed particularly higher levels of bisphenol-A, of monobenzyl phthalate, and of two 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TXIB) metabolites among Nunavimmiut compared to the general Canadian population, notably among women and Ungava Bay residents. Larger studies are required to confirm our findings and identify potential adverse health effects from these exposures.
  • PublicationAccès libre
    Associations between dietary profiles and perfluoroalkyl acids in Inuit youth and adults
    (Elsevier, 2022-10-22) Aker, Amira; Ayotte, Pierre; Caron-Beaudoin, Élyse; De Silva, Amila; Ricard, Sylvie; Lemire, Mélanie
    Background: Perfluoroalkyl acids (PFAAs), a subset of perfluoroalkyl substances (PFAS), are synthetic chemicals used in industrial and consumer applications. They are exceptionally stable and highly mobile in the environment, and were detected in high concentrations in Arctic wildlife and Nunavik Inuit. The study's objective was to study the association between dietary profiles in Nunavik and plasma PFAAs concentrations. Methods: The study used data from the Qanuilirpitaa? 2017 Nunavik Inuit Health Survey (Q2017) (N = 1172) on Inuit adults aged 16-80 years. Nine PFAAs congeners were measured in plasma samples (six were detected). Dietary profiles were identified using latent profile analysis. Two sets of dietary profiles were included; the first included market (store-bought) and country foods (harvested/hunted from the land), and the second included only country foods. Multiple linear regression models regressed log-transformed PFAAs concentrations against the dietary profiles, adjusting for sociodemographic variables. Results: We identified statistically significant 24.54-57.55 % increases in all PFAAs congeners (PFOA, PFNA, PFDA, PFUnDA, PFHxS, and PFOS) in the dietary profile defined by frequent country food consumption compared to the dietary profile defined by frequent market food consumption. Individuals defined by low consumption of foods (related to food insecurity) had higher concentrations of six PFAAs compared to individuals with frequent market food consumption. The associations were stronger with profiles defined by more frequent country food consumption, and particularly those with increased marine mammal consumption. PFDA, PFUnDA, and PFOS were particularly associated with high country food consumption frequency, such that their concentrations increased by approximately 67-83 % compared to those reporting no or very little consumption of any country foods. Conclusions: Increased country food consumption was strongly associated with higher PFAAs concentrations, particularly PFOS, PFDA, and PFUnDA. The results provide further evidence that the quality of country foods is being threatened by PFAAs contamination. Additional national and international regulations are required to protect the Arctic and its inhabitants from these pollutants.
  • PublicationAccès libre
    Perfluoroalkyl acid and bisphenol-A exposure via food sources in four First Nation communities in Quebec, Canada
    (London : CAB International, 2022-03-11) Dubeau, Claudelle; Aker, Amira; Caron-Beaudoin, Élyse; Ayotte, Pierre; Blanchette, Caty; Gros-Louis McHugh, Nancy; Lemire, Mélanie
    Objective: To document perfluoroalkyl acids (PFAA) and bisphenol-A (BPA) exposure in four First Nation communities in northern Quebec compared with the Canadian Health Measures Survey (CHMS Cycle 5 2016–2017) and examine the associations between dietary consumption and chemical exposure. Design: We used cross-sectional data from the JES-YEH! project conducted in collaboration with four First Nation communities in 2015. A FFQ collected information on diet, and PFAA and BPA were measured in biological samples. We used generalised linear models to test the associations between food intake and chemical biomarkers. Setting: Northern Quebec. Participants: Youth aged 3–19 years (n 198). Results: Mean perfluorononanoic acid (PFNA) levels were significantly higher in JES-YEH! than CHMS, and BPA levels were higher among those aged 12–19 years compared with CHMS. Dairy products were associated with PFNA among Anishinabe and Innu participants (geometric mean ratio 95 % CI: 1·53 (95 % CI 1·03, 2·29) and 1·52 (95 % CI 1·05, 2·20), respectively). PFNA was also associated with ultra-processed foods (1·57 (95 % CI 1·07, 2·31)) among Anishinabe, and with wild fish and berries (1·44 (95 % CI 1·07, 1·94); 1·75 (95 % CI 1·30, 2·36)) among Innu. BPA was associated with cheese (1·72 (95 % CI 1·19, 2·50)) and milk (1·53 (95 % CI 1·02, 2·29)) among Anishinabe, and with desserts (1·71 (95 % CI 1·07, 2·74)), processed meats (1·55 (95 % CI 1·00, 2·38)), wild fish (1·64 (95 % CI 1·07, 2·49)) and wild berries (2·06 (95 % CI 1·37, 3·10)) among Innu. Conclusions: These results highlight the importance of better documenting food-processing and packaging methods, particularly for dairy products, and their contribution to endocrine disruptors exposures as well as to promote minimally processed and unpackaged foods to provide healthier food environments for youth in Indigenous communities and beyond.
  • PublicationAccès libre
    Prenatal, concurrent, and sex-specific associations between blood lead concentrations and IQ in preschool canadian children
    (2018-11-02) Boivin, Michel; Ouellet, Emmanuel.; Arbuckle, Tye, E.; Forget-Dubois, Nadine; Fraser, William Donald; Desrochers-Couture, Mireille; Séguin, Jean R.; Oulhote, Youssef; Ayotte, Pierre; Muckle, Gina; Lanphear, Bruce P.
    Background Lead exposure predicts altered neurodevelopment and lower intelligence quotient (IQ) in children, but few studies have examined this association in children who have relatively low blood lead concentrations. Objectives To test the associations between blood lead concentrations and cognitive function in Canadian preschoolers, with a possible moderation by sex. Methods The data were gathered from 609 mother-child pairs from the Maternal–Infant Research on Environmental Chemicals (MIREC) Study. Lead was measured in umbilical and maternal blood, and in children's venous blood at age 3–4 years. Cognitive function was measured with the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) at 3–4 years. We tested the relationship between WPPSI-III scores and blood lead concentrations with multiple linear regression, adding child sex as a moderator. Results Median blood lead concentrations for the mother at 1st trimester and 3rd trimester of pregnancy, and for cord and child blood were 0.60 μg/dL, 0.58 μg/dL, 0.79 μg/dL and 0.67 μg/dL, respectively. We found no association between cord blood lead concentrations and WPPSI-III scores in multivariable analyses. However, cord blood lead concentrations showed a negative association with Performance IQ in boys but not in girls (B = 3.44; SE = 1.62; 95% CI: 0.82, 5.98). No associations were found between WPPSI-III scores and prenatal maternal blood or concurrent child blood lead concentrations. Conclusions Prenatal blood lead concentrations below 5 μg/dL were still associated with a decline in cognitive function in this Canadian cohort, but only for boys.
  • PublicationAccès libre
    Estradiol metabolites as biomarkers of endometrial cancer prognosis after surgery
    (Pergamon Press, 2017-10-29) Turcotte, Véronique; Audet-Delage, Yannick; Guillemette, Chantal; Caron, Patrick; Ayotte, Pierre; Plante, Marie; Villeneuve, Lyne; Simonyan, David; Grégoire, Jean
    Endometrial cancer (EC) is the most common gynecologic malignancy prevailing after menopause. Defining steroid profiles may help predict the risk of recurrence after hysterectomy, which remains limited due to the lack of reliable markers. Adrenal precursors, androgens, parent estrogens and catechol estrogen metabolites were measured by mass spectrometry (MS) in preoperative serums and those collected one month after hysterectomy from 246 newly diagnosed postmenopausal EC cases. We also examined the associations between steroid hormones and EC status by including 110 healthy postmenopausal women. Steroid concentrations were analyzed in relation to clinicopathological features, recurrence and overall survival (OS). The mean follow-up time was 65.5 months and 26 patients experienced relapse after surgery for a recurrence incidence of 10.6% (6.4% Type I and 29.5% Type II). Recurrence and OS were related to a more aggressive disease but not linked to body mass index. Preoperative levels of estriol (E3) and estrone-sulfate (E1-S) were inversely associated with recurrence in a multivariate logistic regression analysis (Hazard ratios (HRs) of 0.31, P = 0.039 and 3.01, P = 0.024; respectively). All circulating steroids declined considerably after surgery almost reaching those of healthy women, except 4-methoxy-E2 (4MeO-E2) for which postoperative levels increased by 35% and were associated to a 68% decreased risk of recurrence (HR = 0.32, P = 0.015). Women diagnosed with both histological types of EC present significantly higher levels of steroids, in support of their mitogenic effects. The estrogen precursor E1-S, the anticancer metabolite 4MeO-E2, and E3 that exert mixed antagonist and agonist estrogenic activities and immunological effects, are potential independent prognostic factors.
  • PublicationAccès libre
    Determinants of selenoneine concentration in red blood cells of Inuit from Nunavik (Northern Québec, Canada)
    (Elsevier Inc., 2019-03-28) Lemire, Mélanie; Little, Matthew; Achouba, Adel; Ayotte, Pierre; Dumas, Marie-Pierre; Ouellet, Nathalie
    Selenium (Se) is a trace mineral essential to human health, and is especially abundant in marine foods consumed by Inuit populations in Nunavik (northern Quebec, Canada), leading to exceptionally high whole blood Se levels. While most epidemiological studies to date examine plasma or whole blood Se, little is known about the health implications of specific Se biomarkers (e.g. selenoproteins and small Se compounds). Selenoneine, a novel Se compound, is found in high concentrations in marine foods (and particularly beluga mattaaq) and the red blood cells (RBCs) of populations that consume them. We report here RBC selenoneine concentrations in a population of Inuit adults (n = 885) who participated in the Qanuippitaa? 2004 survey. Simple associations between RBC selenoneine and other Se and mercury (Hg) biomarkers were assessed using Spearman correlations and linear regressions. Wilcoxon ranksum tests were used to examine differences in biomarkers and characteristics between tertiles of RBC selenoneine concentration. A multiple linear regression analysis was used to determine factors (sociodemographic, lifestyle, and dietary) associated with RBC selenoneine concentrations. Selenoneine comprised a large proportion of whole blood Se and RBC Se in this population. Age and sex-adjusted geometric mean RBC selenoneine concentration was 118 μg/L (range: 1-3226 μg/L) and was much higher (p = 0.001) among women (150.3 μg/L) than men (87.6 μg/L) across all regions of Nunavik after controlling for age, region, and diet. RBC selenoneine was highly correlated with RBC Se (rs = 0.96, p < 0.001) and whole blood Se (rs = 0.89, p < 0.001), but only weakly correlated with plasma Se (rs = 0.13, p < 0.001). Overall, increasing age (standardized β = 0.24), higher body-mass index (BMI; β = 0.08), female sex (β = 0.10), living in a Hudson Strait community (compared to Hudson Bay and Ungava Bay; β = 0.38), and consuming beluga mattaaq (g/day; β = 0.19) were positively associated with RBC selenoneine. Meanwhile, consumption of market meats (g/day; β = -0.07) was negatively associated with RBC selenoneine. RBC selenoneine is an important biomarker of Se dietary intake from local marine foods in Inuit populations. Further studies are needed to examine the health effects of selenoneine intake and the underlying mechanisms for sex differences among Inuit populations.
  • PublicationAccès libre
    Sociodemographic patterning of dietary profiles among Inuit youth and adults in Nunavik, Canada: a cross-sectional study
    (Canadian Public Health Association, 2022-12-08) Aker, Amira; Ayotte, Pierre; Furgal, Chris; Kenny, Tiff-Annie; Little, Matthew; Gauthier, Marie-Josée; Bouchard, Amélie; Lemire, Mélanie
    Objectives Country (traditional) foods are integral to Inuit culture, but market food consumption is increasing. The Qanuilirpitaa? 2017 Nunavik Health Survey (Q2017) reported similar country food consumption frequency compared to that in 2004; however, examining food items individually does not account for diet patterns, food accessibility, and correlations between food items. Our objective was to identify underlying dietary profiles and compare them across sex, age, ecological region, and food insecurity markers, given the links among diet, health, and sociocultural determinants. Methods Food frequency and sociodemographic data were derived from the Q2017 survey (N = 1176). Latent profile analysis identified dietary profiles using variables for the relative frequencies of country and market food consumption first, followed by an analysis with those for country food variables only. Multinomial logistic regression examined the associations among dietary profiles, sociodemographic factors, and food insecurity markers (to disassociate between food preferences and food access). Results Four overall dietary profiles and four country food dietary profiles were identified characterized by the relative frequency of country and market food in the diet. The patterns were stable across several sensitivity analyses and in line with our Inuit partners’ local knowledge. For the overall profiles, women and adults aged 30–49 years were more likely to have a market food–dominant profile, whereas men and individuals aged 16–29 and 50+ years more often consumed a country food–dominant profile. In the country food profiles, Inuit aged 16–29 years were more likely to have a moderate country food profile whereas Inuit aged 50+ were more likely to have a high country food–consumption profile. A low country and market food–consumption profile was linked to higher prevalence of food insecurity markers. Conclusion We were able to identify distinct dietary profiles with strong social patterning. The profiles elucidated in this study are aligned with the impact of colonial influence on diet and subsequent country food promotion programs for Inuit youth. These profiles will be used for further study of nutritional status, contaminant exposure, and health to provide context for future public health programs.