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Personne :
Gagnon, Jean-François

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Gagnon

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Jean-François

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Université Laval. École de Psychologie

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ncf11848539

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Voici les éléments 1 - 4 sur 4
  • PublicationAccès libre
    Normative data for the rey auditory verbal learning test in the older French-Quebec population
    (Swets Pub. Service, 2018-02-01) Lavoie, Monica; Gagnon, Jean-François; Joubert, Sven; Rouleau, Isabelle; Macoir, Joël; Hudon, Carol; Bherer, Louis; Blanchet, Sophie
    Objective: The aim of this study was to establish normative data for the Rey Auditory Verbal Learning Test, a test assessing verbal episodic memory, in the older French-Quebec population. Method: A total of 432 French-speaking participants aged between 55 and 93 years old, from the Province of Quebec (Canada), were included in the study. Using multiple regression analyses, normative data were developed for five variable of interest, namely scores on trial 1, sum of trials 1 to 5, interference list B, immediate recall of list A, and delayed recall of list A. Results: Results showed that age, education, and sex were associated with performance on all variables. Equations to calculate the expected score for a participant based on sex, age, and education level as well as the Z score were developed. Conclusion: This study provides clinicians with normative data that take into account the participants’ sociodemographic characteristics, thus giving a more accurate interpretation of the results.
  • PublicationAccès libre
    Full sequencing and haplotype analysis of MAPT in Parkinson disease and REM sleep behavior disorder
    (Raven Press, 2018-05-14) Li, Jiao; Boivin, Michel; Ruskey, Jennifer A.; Dupré, Nicolas; Arnulf, Isabelle; Gagnon, Jean-François; Dauvilliers, Yves; Labbé, Catherine; Hu, Michele T.M.; Högl, Birgit; Leblond, Claire S.; Zhou, Sirui; Ambalavanan, Amirthagowri; Ross, Jay P.; Bourassa, Cynthia V.; Spiegelman, Dan; Laurent, Sandra B.; Stefani, Ambra; Charley Monaca, Christelle; Cochen De Cock, Valérie; Ferini-Strambi, Luigi; Plazzi, Giuseppe; Antelmi, Elena; Young, Peter; Heidbreder, Anna; Ferman, Tanis J.; Dion, Patrick A.; Fan, Dongsheng; Desautels, Alex; Fon, Edward A.; Montplaisir, Jacques Y.; Boeve, Bradley F.; Postuma, Ronald B.; Rouleau, Guy A.; Ross, Owen A.; Gan-Or, Ziv
    Background: MAPThaplotypes are associated withPD, but their association with rapid eye movementsleep behavior disorder is unclear. Objective: To study the role of MAPT variants in rapideye movement sleep behavior disorder. Methods: Two cohorts were included: (A) PD (n5600),rapid eye movement sleep behavior disorder (n5613)patients, and controls (n5981); (B) dementia withLewy bodies patients with rapid eye movement sleepbehavior disorder (n5271) and controls (n5950).MAPT-associated variants and the entire codingsequence ofMAPTwere analyzed. Age-, sex-, andethnicity-adjusted analyses were performed to examinethe association betweenMAPT, PD, and rapid eyemovement sleep behavior disorder.Results:MAPT-H2 variants were associated with PD(odds ratios: 0.62-0.65;P50.010-0.019), but not withrapid eye movement sleep behavior disorder. In PD,the H1 haplotype odds ratio was 1.60 (95% confidenceinterval: 1.12-2.28;P50.009), and the H2 odds ratiowas 0.68 (95% confidence interval: 0.48-0.96; P50.03). The H2/H1 haplotypes were not associatedwith rapid eye movement sleep behavior disorder.Conclusions:Our results confirm the protective effectof theMAPT-H2 haplotype in PD, and define its com-ponents. Furthermore, our results suggest thatMAPTdoes not play a major role in rapid eye movementsleep behavior disorder, emphasizing different geneticbackground than in PD in this locus.
  • PublicationAccès libre
    Behavioral and psychological symptoms that predict cognitive decline or impairment in cognitively normal middle-aged or older adults : a meta-analysis
    (Springer, 2020-05-11) Croteau, Jordie; Escudier, Frédérique; Zomahoun, Hervé Tchala Vignon; De Roy, Jessie; Parent, Andréanne; Gagnon, Jean-François; Cross, Nathan; Hudon, Carol; Dang-Vu, Thien Thanh; Grenier, Sébastien; Bruneau, Marie-Andrée; Belleville, Sylvie
    Epidemiological studies have revealed that behavioral and psychological (or non-cognitive) symptoms are risk factors for cognitive decline in older adults. This study aimed to systematically review the literature and determine which behavioral and psychological symptoms are most predictive of future cognitive decline among individuals with no pre-existing cognitive impairments. The selected studies included middle-aged or older adults without cognitive impairments. The predictors were assessed using behavioral and psychological questionnaires, or diagnostic interviews, to identify non-cognitive symptoms or psychiatric clinical conditions. The follow-up period was at least one year, and the design of the selected studies was either retrospective or prospective. This study compared individuals with and without non-cognitive manifestations and resulted in one of three outcomes: (a) a score change on a cognitive measure, (b) a diagnosis of mild cognitive impairment, or (c) a diagnosis of Alzheimer's disease or dementia. Four online databases were searched for eligible studies from the database inception to January 17, 2017: MEDLINE (PubMed), Embase (OVID), PsycINFO, and Web of Science. Pooled effect sizes were estimated using a random-effect model. Higgins I2, the Q statistic, and tau-squared were used to quantify the observed heterogeneity between the studies. Results indicate that depression and sleep duration (long and short) were the most consistent associations between behavioral or psychological symptoms and cognitive decline. This meta-analysis supports the need to assess behavioral and psychological symptoms in cognitively intact older adults to identify those who are at risk for cognitive decline.
  • PublicationAccès libre
    Trail making test A and B : regression-based normative data for Quebec french-speaking mid and older-aged adults
    (Swets Pub. Service, 2018-05-04) Potvin, Olivier; Parent, Camille; Wilson, Maximiliano Agustin; Gagnon, Jean-François; St-Hilaire, Alexandre; Rouleau, Isabelle; Joubert, Sven; Macoir, Joël; Belleville, Sylvie; Hudon, Carol; Bherer, Louis; Koski, Lisa
    Objective: The Trail Making Test (TMT) is mainly used to assess visual scanning/processing speed (part A) and executive functions (part B). The test has proven sensitive at detecting cognitive impairment during aging. However, previous studies have shown differences between normative data from different countries and cultures, even when corrected for age and education. Such inconsistencies between normative data may lead to serious diagnostic errors, thus, the development of local norms is warranted. The purpose of this study was to provide regression-based normative data for TMT-A and -B, tailored for a large sample of French-speaking adults from Quebec (Canada). Method: The normative sample consisted of 792 participants aged 50–91 years. Based on multiple linear regression, equations to calculate Z-scores were provided for TMT-A and -B, and for a contrast score which compared performance between TMT-A and -B. Percentiles, stratified by age, are presented for the number of recorded errors. Results: Age was a significant predictor for TMT-A performance, while age and education were independently associated with performance on TMT-B. Gender did not have any effect on performance, in either condition. Education was the only significant predictor of the contrast score between TMT-B and TMT-A. Examiners should remain vigilant when two or more errors are recorded on the TMT-B since this was uncommon in the normative sample. Conclusions: Our TMT normative data improve the accurate detection of visual scanning/processing speed and executive function deficits in Quebec (Canada) French-speaking adults.