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Personne :
Hachicha, Zeineb

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Hachicha

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Zeineb

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Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval

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  • PublicationRestreint
    Usefulness of the valvuloarterial impedance to predict adverse outcome in asymptomatic aortic stenosis
    (Elsevier Biomedical, 2009-09-08) Hachicha, Zeineb; Pibarot, Philippe; Dumesnil, Jean G.
    Objectives: This study was designed to examine the prognostic value of valvuloarterial impedance (Z(va)) in patients with aortic stenosis (AS). Background: We previously showed that the Z(va) is superior to standard indexes of AS severity in estimating the global hemodynamic load faced by the left ventricle (LV) and predicting the occurrence of LV dysfunction. This index is calculated by dividing the estimated LV systolic pressure (systolic arterial pressure + mean transvalvular gradient) by the stroke volume indexed for the body surface area. Methods: We retrospectively analyzed the clinical and echocardiographic data of 544 consecutive patients having at least moderate AS (aortic jet velocity > or =2.5 m.s(-1)) and no symptoms at baseline. The primary end point for this study was the overall mortality regardless of the realization of aortic valve replacement (AVR). Results: Four-year survival was significantly (p < 0.001) lower in the patients with a baseline Z(va) > or =4.5 mm Hg x ml(-1) x m(2) (65 +/- 5%) compared with those with Z(va) between 3.5 and 4.5 mm Hg x ml(-1) x m(2) (78 +/- 4%) and those with Z(va) < or =3.5 mm Hg x ml(-1) x m(2) (88 +/- 3%). The risk of mortality was increased by 2.76-fold in patients with Z(va) > or =4.5 mm Hg x ml(-1) x m(2) and by 2.30-fold in those with a Z(va) between 3.5 and 4.5 mm Hg x ml(-1) x m(2) after adjusting for other risk factors and type of treatment (surgical vs. medical). Conclusions: Increased Z(va) is a marker of excessive LV hemodynamic load, and a value >3.5 successfully identifies patients with a poor outcome. These findings suggest that beyond standard indexes of stenosis severity, the consideration of Z(va) may be useful to improve risk stratification and clinical decision making in patients with AS.
  • PublicationRestreint
    Usefulness of exercise-stress echocardiography for risk stratification of true asymptomatic patients with aortic valve stenosis
    (European Society of Cardiology, 2010-03-21) Maréchaux, Sylvestre; Blais, Agnès; Bergeron, Sébastien; Bellouin, Annaïk; Hachicha, Zeineb; Pibarot, Philippe; Meimoun, Patrick; Dumesnil, Jean G.; Arsenault, Marie; Le Tourneau, Thierry; Ennezat, Pierre-Vladimir
    Aims : Abnormal exercise test defined as the occurrence of exercise limiting symptoms, fall in blood pressure below baseline, or complex ventricular arrhythmias is useful to predict clinical events in asymptomatic patients with aortic stenosis (AS). The purpose of this study was to determine whether exercise-stress echocardiography (ESE) adds any incremental prognostic value to resting echocardiography in patients with AS having a normal exercise response. Methods and results : One hundred and eighty-six asymptomatic patients with at least moderate AS and preserved LV ejection fraction (=50%) were assessed by Doppler-echocardiography at rest and during a maximum ramp semi-supine bicycle exercise test. Fifty-one (27%) patients had an abnormal exercise test and were excluded from the present analysis. Among the 135 patients with normal exercise test, 67 had an event (aortic valve replacement motivated by symptoms or cardiovascular death) at a mean follow-up of 20+14 months. The variables independently associated with events were: age =65 years [hazard ratio (HR) ¼ 1.96; 95% confidence interval (CI): 1.15–3.47; P ¼ 0.01], diabetes, (HR ¼ 3.20; 95% CI: 1.33–6.87; P ¼ 0.01), LV hypertrophy (HR ¼ 1.96; 95% CI: 1.17–3.27; P ¼ 0.01), resting mean gradient .35 mmHg (HR ¼ 3.60; 95% CI: 2.11–6.37; P , 0.0001), and exercise-induced increase in mean gradient .20 mmHg (HR ¼ 3.83; 95% CI: 2.16–6.67; P , 0.0001). Conclusion : The exercise-induced increase in transvalvular gradient may be helpful to improve risk stratification in asymptomatic AS patients with normal exercise response. These results thus suggest that ESE may provide additional prognostic information over that obtained from standard exercise testing and resting echocardiography.