Pour savoir comment effectuer et gérer un dépôt de document, consultez le « Guide abrégé – Dépôt de documents » sur le site Web de la Bibliothèque. Pour toute question, écrivez à corpus@ulaval.ca.
 

Personne :
Joanisse, Denis R.

En cours de chargement...
Photo de profil

Adresse électronique

Date de naissance

Projets de recherche

Structures organisationnelles

Fonction

Nom de famille

Joanisse

Prénom

Denis R.

Affiliation

Université Laval. Département de kinésiologie

ISNI

ORCID

Identifiant Canadiana

ncf11860388

person.page.name

Résultats de recherche

Voici les éléments 1 - 1 sur 1
  • PublicationRestreint
    Irisin is more strongly predicted by muscle oxidative potential than adiposity in non-diabetic men
    (Springer Science & Business Media B.V., 2015-03-28) Joanisse, Denis R.; Dubois, Marie Julie; Marette, André; Fleury, Pascale; Tremblay, Angelo; Lacaille, Michel; Weisnagel, John; Huth, Claire; Mauriege, Pascale
    Numerous controversies surround the peptide hormone irisin. Although implicated as a myokine promoting the browning of adipose tissue in rodents, its roles in humans remain unclear. Contradictory results have also been found with respect to the relationships between adiposity or metabolic health and plasma irisin levels in humans. We investigated the relationship between irisin levels and body composition (hydrostatic weighing), insulin sensitivity (hyperinsulinemiceuglycemic clamp), fitness level (ergocycle VO2max) and skeletal muscle metabolic profile in 53 men (aged 34–53 years) from four groups: sedentary non-obese controls (body mass index [BMI] <25 kg/m2), sedentary obese (BMI >30 kg/m2), sedentary obese glucose-intolerant, and non-obese highly trained endurance active. Baseline plasma irisin levels were significantly different between groups, being lowest in trained men (140.6±38.2 ng/mL) and highest in metabolically deteriorated glucose-intolerant subjects (204.0±50.5 ng/mL; ANOVA p=0.01). Including all subjects, irisin levels were positively associated with adiposity (e.g. fat mass, r=0.430, p<0.01) and negatively associated with fitness (r=-0.369, p<0.01), insulin sensitivity (M/I, r=-0.355, p<0.01) and muscle citrate synthase (CS) activity (r=-0.482, p<0.01). Most correlations lost statistical significance when excluding active individuals, except for insulin resistance (r=-0.413, p<0.01) and CS (r=-0.462, p<0.01). Multiple regression analyses reveal CS as the strongest independent predictor of irisin levels (r2 range 0.214 to 0.237). We conclude that muscle oxidative potential is an important factor linked to circulating irisin levels. Keywords : Irisin . Myokine . Adipose tissue . Adipokine . Obesity. Insulin sensitivity