Personne : Laurin, Danielle
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Laurin
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Danielle
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Université Laval. Faculté de pharmacie
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ncf10329294
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Publication Accès libre L’incontinence urinaire, parlons-en!(Point en santé et services sociaux, 2017-02-01) Laurin, Danielle; Turpin, Rachel; Sirois, CarolineL’incontinence urinaire est la difficulté à contrôler sa vessie, un problème fréquent chez la personne âgée. Même si elle ne fait pas partie du vieillissement normal, plusieurs problèmes liés à l’âge augmentent le risque d’en souffrir. L’incontinence urinaire peut avoir un impact important sur la qualité de vie. Elle cause des émotions négatives chez les personnes touchées. Plusieurs hésitent à discuter de ce problème, car elles pensent qu’il n’existe aucune solution. Au contraire, l’incontinence urinaire peut être guérie, traitée ou contrôlée de diverses façons.Publication Accès libre Vitamin D status, cognitive decline and incident dementia : the Canadian Study of Health and Aging(Canadian Public Health Association, 2020-02-03) Tourigny, André; Talbot, Denis; Laurin, Danielle; Nafti, Mohamed; Carmichael, Pierre-Hugues; Dodin-Dewailly, Sylvie; Giguère, Yves.; Duchaine, Caroline S.Objective: Vitamin D could prevent cognitive decline because of its neuroprotective, anti-inflammatory and antioxidant properties. This study aimed to evaluate the associations of plasma 25-hydroxyvitamin D (25(OH)D) concentrations with global cognitive function and incident dementia, including Alzheimer’s disease (AD). Methods: The Canadian Study of Health and Aging is a 10-year cohort study of a representative sample of individuals aged 65years or older. A total of 661 subjects initially without dementia with frozen blood samples and follow-up data were included. Global cognitive function was measured using the validated Modified Mini-Mental State (3MS) examination. A consensus diagnosis of all-cause dementia and AD was made between the physician and the neuropsychologist according to published criteria. Cognitive decline for a 5-year increase in age at specific 25(OH)D concentrations was obtained using linear mixedmodels with repeated measures. Hazard ratios of incident dementia and AD were obtained using semi-parametric proportionalhazards models with age as time scale. Results: Over a mean follow-up of 5.4 years, 141 subjects developed dementia of which 100 were AD. Overall, no significant association was found between 25(OH)D and cognitive decline, dementia or AD. Higher 25(OH)D concentrations were associated with an increased risk of dementia and AD in women, but not in men. Conclusion: This study does not support a protective effect of vitamin D status on cognitive function. Further research is needed toclarify the relation by sex.Publication Accès libre Is benzodiazepine use associated with the risk of dementia and cognitive impairment-not dementia in older persons? The Canadian study of health and aging(Sage, 2019-10-09) Laurin, Danielle; Kröger, Edeltraut; Nafti, Mohamed; Carmichael, Pierre-Hugues; Sirois, CarolineBackground : The use of benzodiazepines in relation to cognitive decline remains an area of controversy in aging populations. Objective: This study aims to evaluate the risk of cognitive impairment–not dementia (CIND), Alzheimer disease (AD), and all-cause dementia with benzodiazepine use. The effect modification by sex was also investigated. Methods : Data come from the Canadian Study of Health and Aging, a 10-year multicentric study involving 10 263 participants randomly selected, 65 years and older, living in the community and in institutions. Current exposure to benzodiazepines was assessed in a face-to-face interview or self-reported in a questionnaire. Cox proportional hazard regression models, using age as time scale, were conducted to estimate hazard ratios, with adjustment for sex, education, smoking, alcohol intake, depression, physical activity, nonsteroidal anti-inflammatory drug use, and vascular comorbidities. Results : Data sets included 5281 participants for dementia as the outcome, 5015 for AD, and 4187 for CIND. Compared with nonusers, current use of benzodiazepines was associated with an increased risk of CIND (hazard ratio = 1.36; 95% CI = 1.08-1.72) in the simplest model. Results remained similar in the fully adjusted model (hazard ratio = 1.32; 95% CI = 1.04-1.68). There was no association between benzodiazepine use and the risk of dementia or AD. All these effects were similar between men and women. Conclusion and Relevance : Benzodiazepine use in older people from the general population is related to subsequent occurrence of cognitive dysfunction but not implicated in the pathogenesis of dementia or AD. Caution should be exercised when prescribing benzodiazepines to preserve global cognitive function.