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Personne :
Biron, Simon

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Biron

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Simon

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Université Laval. Département de chirurgie

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ncf10414694

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Voici les éléments 1 - 5 sur 5
  • PublicationRestreint
    Waist girth does not predict metabolic complications in severely obese men
    (American Diabetes Association, 2006-05-26) Drapeau, Vicky; Biron, Simon; Mauriege, Pascale; Richard, Denis; Marceau, Picard; Lemieux, Isabelle.; Bergeron, Jean
    The epidemic of obesity has received considerable attention because of its increasing prevalence and its deleterious impact on health. In this regard, the metabolic syndrome has been recognized as a prevalent cause of cardiovascular disease, and the National Cholesterol Education Program Adult Treatment Panel III guidelines have proposed clinical tools for the identification of individuals characterized by this syndrome. However, there is considerable metabolic heterogeneity among equally overweight/ obese individuals. While some patients show a relatively “normal” metabolic risk profile despite being obese, others who are moderately overweight can nevertheless be characterized by metabolic complications. Thus, it is not uncommon to find severely obese patients with minimal changes in their metabolic risk profile, suggesting that they may be at lower cardiovascular disease risk than what could be expected from their massive obesity. Therefore, the aim of the present study was to examine the relationships between selected features of the metabolic syndrome and waist circumference as a crude marker of abdominal obesity in moderately and severely obese men.
  • PublicationRestreint
    ZFP36 : a promising candidate gene for obesity-related metabolic complications identified by converging genomics
    (Springer, 2007-03-31) Biron, Simon; Lescelleur, Odette; Vohl, Marie-Claude; Marceau, Simon; Deshaies, Yves; Bouchard, Luigi; Tchernof, André
    Background : Few genes have been associated with the metabolic syndrome (MS), although its genetic component is well accepted. The aim of this study was to compare the adipose tissue gene expression profiles of obese men with and without the MS and to apply an integrative genomic approach to propose new candidate genes. Methods : Affymetrix HG-U133 plus 2 arrays have been used for expression profiling of omental adipose tissue of non-diabetic obese men with (n=7) and without (n=7) the MS, as defined by the NCEP-ATPIII, that undergo a bariatric operation. Results ; Omentum expresses a total of 23 055 transcripts. Overall, 489 genes were differentially expressed between the two groups. A total of 80 differentially expressed genes were located within a previously identified region of linkage. In this subset of genes, zinc finger protein 36 (ZFP36) gene has been identified as the most promising genetic target for the MS-based mean fold expression differences and on biological plausibility. 2 out of 5 identified ZFP36 gene polymorphisms have been genotyped in a cohort of 698 obese subjects. The minor allele of these polymorphisms was associated with a lower body weight in women (rs251864; P≤0.01) and glucose level in men (c.1564_1565delTT; P<0.05). The haplogenotype was associated with plasma LDL-cholesterol levels in men and women (P≤0.02), and weight in women (P≤0.05). The haplogenotype was also associated with omental adipose tissue ZFP36 mRNA levels (n=83 women; P=0.02), and explained 10.1% of its variance. Conclusion : These results suggest that converging genomics is helpful to prioritize MS-related candidate genes and that ZFP36 is a promising candidate gene for obesity-associated metabolic complications.
  • PublicationRestreint
    Metabolic profile in severely obese women is less deteriorated than expected when compared to moderately obese women
    (Springer, 2006-04-01) Drapeau, Vicky; Biron, Simon; Mauriege, Pascale; Tremblay, Angelo; Richard, Denis; Marceau, Picard; Lemieux, Isabelle.; Bergeron, Jean
    Background: Obesity is well known to be associated with an increased prevalence of metabolic complications. Severe obesity is thus expected to have more important alterations of the metabolic profile than moderate obesity. This study aimed to compare the metabolic profile of pre- and postmenopausal severely obese women with moderately obese women. Methods: First, the metabolic profile of pre- (n=165) and postmenopausal (n=43) severely obese women (body mass index (BMI) ≥40 kg/m2) was compared to that of pre- (n=52) and postmenopausal (n=35) moderately obese women (BMI of 30-40 kg/m2). Thereafter, pre- and postmenopausal severely obese women were divided into two subgroups according to the presence/absence of a dysmetabolic profile. We used for comparison, a group of pre- and postmenopausal moderately obese women without a dysmetabolic profile. Results: The metabolic profile of pre- and postmenopausal severely obese women was less deteriorated than expected when compared to moderately obese women. Moreover, severely obese women with or without a dysmetabolic profile displayed comparable or even lower plasma levels of cholesterol, HDL and LDL-cholesterol, and a lower cholesterol/HDL-cholesterol ratio than moderately obese women (P≤0.05). After menopause, the metabolic profile of severely obese women, dysmetabolic or not, was similar to that of moderately obese women. Blood pressure was, however, higher in severely obese women compared to moderately obese women, only before menopause (P≤0.0001). Conclusion: These results indicate that despite their large accumulation of adipose tissue, most of the severely obese women had a metabolic profile less deteriorated than expected, when compared to moderately obese women.
  • PublicationRestreint
    Waist circumference is useless to assess the prevalence of metabolic abnormalities in severely obese women
    (Springer, 2007-07-14) Drapeau, Vicky; Biron, Simon; Mauriege, Pascale; Tremblay, Angelo; Richard, Denis; Marceau, Picard; Lemieux, Isabelle.; Bergeron, Jean
    Background : The present retrospective study aims to provide additional evidence supporting the fact that waist circumference, in severe obesity, is not a good clinical marker to identify individuals with the metabolic syndrome or an altered metabolic profile. Methods : Relationships between waist circumference and metabolic profile of pre- (n = 165) and postmenopausal (n = 43) severely obese women were compared to associations observed in pre- (n = 52) and postmenopausal (n = 35) moderately obese women. Results : Results showed that abdominal obesity assessed by waist circumference was more highly correlated with fasting glycemia, HDL-cholesterol and the cholesterol/HDL-cholesterol ratio in moderately than in severely obese women, before menopause. After menopause, waist circumference was not a valuable predictor of metabolic abnormalities in both groups. Moreover, when waist circumference was included as a criterion of the metabolic syndrome (as defined by the NCEP ATP III guidelines) in severely obese women, the prevalence of this metabolic condition was over-estimated by 72%. Conclusion : These results emphasize the uselessness of waist circumference to assess the prevalence of the metabolic syndrome or an altered metabolic profile in severely obese women.
  • PublicationAccès libre
    Gene expression variability in subcutaneous and omental adipose tissue of obese men
    (Chicago Medical Press, 2006-12-31) Biron, Simon; Richard, Denis; Marceau, Picard; Bossé, Yohan; Lebel, Stéfane; Vohl, Marie-Claude; Zhang, Yonghua; Tchernof, André
    We investigated interindividual variability in gene expression in abdominal subcutaneous (SC) and omental (OM) adipose tissue of 10 massively obese men. Affymetrix human U133A microarrays were used to measure gene expression levels. A total of 6811 probesets generated significant signal in both depots in all samples. Interindividual variability in gene expression was rather low, with more than 90% of transcripts showing a coefficient of variation (CV) lower than 23.6% and 21.7% in OM and SC adipose tissues, respectively. The distributions of CV were similar between the two fat depots. A set of highly variable genes was identified for both tissues on the basis of a high CV and elevated gene expression level. Among the set of highly regulated genes, 18 transcripts were involved in lipid metabolism and 28 transcripts were involved in cell death for SC and OM samples, respectively. In conclusion, gene expression interindividual variability was rather low and globally similar between fat compartments, and the adipose tissue transcriptome appeared as relatively stable, although specific pathways were found to be highly variable in SC and OM depots.