Personne :
Gauthier, Julie

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Gauthier
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Julie
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Département de psychiatrie et de neurosciences, Faculté de médecine, Université Laval
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  • Publication
    Restreint
    The axonal arborization of single nigrostriatal neurons in rats
    (ANKHO International Inc., 1999-07-12) Gauthier, Julie; Lévesque, Martin; Parent, Martin; Parent, André
    Neurons of the substantia nigra pars compacta (SNc) were iontophoretically injected with biotin dextran and their anterogradely labeled axons individually reconstructed from serial sagittal sections. Most nigrostriatal axons travelled directly to the striatum, where they branched abundantly. Other axons arborized profusely in various extrastriatal structures, including the globus pallidus, the entopeduncular and subthalamic nuclei, and branched only sparsely in the striatum. This heterogeneous organization of the nigrostriatal projection allows single SNc neurons to influence differently striatal neurons and to act directly upon extrastriatal components of the basal ganglia via a highly patterned set of collaterals.