Usefulness of NT-pro BNP monitoring to identify echocardiographic responders following cardiac resynchronization therapy

Authors: Magne, JulienDubois, MichelleChampagne, JeanDumesnil, Jean G.Pibarot, PhilippePhilippon, FrançoisO'Hara, GillesSénéchal, Mario
Abstract: Background: Cardiac resynchronization therapy (CRT) improves left ventricular (LV) volumes, mitral regurgitation (MR) severity and symptoms of patients with heart failure (HF). However, = 30% of patients have no significant clinical or echocardiographic improvement following CRT. Reverse remodeling after CRT correlates with improved clinical outcomes. We hypothesized that in NT-pro BNP monitoring is accurate to identify responders following CRT. Methods: 42 consecutive patients (mean age 66 ± 12 years, male 68%) with HF undergoing CRT were prospectively enrolled. Responders at follow-up were defined by echocardiography (decrease in LV end systolic volume = 15%). Echocardiography and NT-pro BNP measurement were performed at baseline and repeated 3 to 6 month after CRT. Results: There was no significant difference between responders (n = 29, 69%) and non-responders (n = 13, 31%) regarding baseline NT-pro BNP level. Responders had significantly higher decrease in NT-pro BNP levels during follow-up than non-responders (absolute: -1428 ± 1333 pg.ml -1 vs. -61 ± 959 pg.ml -1 , p = 0.002; relative: -45 ± 28% vs. 2 ± 28%, p < 0.0001). A decrease of = 15% in NT-pro BNP 3–6 months after CRT identifies echocardiographic responders with a sensitivity of 90% and a specificity of 77%. Conclusion: NT-pro BNP monitoring can accurately identify echocardiographic responders after CRT.
Document Type: Article de recherche
Issue Date: 20 August 2009
Open Access Date: 11 July 2016
Document version: VoR
Permalink: http://hdl.handle.net/20.500.11794/8429
This document was published in: Cardiovascular Ultrasound, Vol. 7, 39–49 (2009)
https://doi.org/10.1186/1476-7120-7-39
BioMed Central
Alternative version: 10.1186/1476-7120-7-39
19695099
Collection:Articles publiés dans des revues avec comité de lecture

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