Hypoadiponectinemia is associated with valvular inflammation and faster disease progression in patients with aortic stenosis

Authors: Mohty, Dania; Pibarot, PhilippeCôté, NancyCartier, AmélieDesprés, Jean-PierreMathieu, Patrick
Abstract: Objectives: Adiponectin is a protein secreted by adipocytes which has anti-inflammatory properties. The objective of this study was to examine the relationship between adiponectinemia and the hemodynamic progression of aortic stenosis (AS) as well as the degree of inflammation in the valve explanted at the time of aortic valve replacement (AVR). Methods: The plasma level of adiponectin was measured in 122 patients undergoing AVR. The explanted aortic valves were analyzed and the density of leukocytes (CD45+), T cells (CD3+) and blood vessels (von Willebrand factor positive; vWF+) was documented. Also, a subset of patients (n = 67) had ¿2 echocardiographic studies separated by at least 6 months, thereby allowing assessment of the rate of progression of stenosis during the preoperative period. Results: Patients with lower plasma levels of adiponectin (<5.4 µg/ml) had a faster progression rate of the mean transvalvular gradient before surgery than those with higher levels (9 ± 1 vs. 4 ±1 mm Hg/year; p = 0.008). Moreover, these patients with hypoadiponectinemia had significantly more leukocytes (CD45+), T cells and blood vessels (vWF+) in their explanted valves compared to those with higher adiponectin levels. Conclusion: These findings support the concept that adiponectin may play a protective role against the inflammatory process and progression of calcific AS.
Document Type: Article de recherche
Issue Date: 19 May 2011
Open Access Date: Restricted access
Document version: VoR
Permalink: http://hdl.handle.net/20.500.11794/7820
This document was published in: Cardiology, Vol. 118 (2), 140-146 (2011)
https://doi.org/10.1159/000327588
S. Karger
Alternative version: 10.1159/000327588
21597293
Collection:Articles publiés dans des revues avec comité de lecture

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