Prosthesis-patient mismatch : definition, clinical impact, and prevention

Authors: Pibarot, PhilippeDumesnil, Jean G.
Abstract: Prosthesis-patient mismatch (PPM) is present when the effective orifice area of the inserted prosthetic valve is too small in relation to body size. Its main haemodynamic consequence is to generate higher than expected gradients through normally functioning prosthetic valves. This review updates the present knowledge about the impact of PPM on clinical outcomes. PPM is common (20–70% of aortic valve replacements) and has been shown to be associated with worse haemodynamic function, less regression of left ventricular hypertrophy, more cardiac events, and lower survival. Moreover, as opposed to most other risk factors, PPM can largely be prevented by using a prospective strategy at the time of operation.
Document Type: Article de recherche
Issue Date: 26 October 2006
Open Access Date: Restricted access
Document version: VoR
Permalink: http://hdl.handle.net/20.500.11794/4708
This document was published in: Heart, Vol. 92 (8), 1022-1029 (2006)
http://dx.doi.org/10.1136/hrt.2005.067363
British Cardiac Society
Alternative version: 10.1136/hrt.2005.067363
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1861088/
Collection:Articles publiés dans des revues avec comité de lecture

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