Genomics : the next step to elucidate the etiology of calcific aortic valve stenosis

Authors: Bossé, YohanMathieu, PatrickPibarot, Philippe
Abstract: With the current shift toward an older population, calcific aortic valve stenosis (AVS) is likely to become a major societal and economic burden. For many years, AVS was regarded as a degenerative and nonmodifiable process. However, molecular studies unanimously demonstrated that AVS is an actively regulated disorder with several potential therapeutic targets. Many factors are predicted to cause AVS, and an important genetic predisposition is anticipated. In this review, we describe candidate genes and signaling pathways identified by genetic research and incorporate this new knowledge into a more comprehensive picture of factors involved in the pathogenesis of AVS. We also emphasize the need for additional studies to elucidate its complete genetic architecture. Recent advances in genomic research offer a remarkable opportunity to investigate AVS at the most fundamental level. The benefits of these new approaches can be observed in many complex diseases, but the field of AVS is trailing behind. We discuss the future utility of these new genomic approaches to improve our understanding of AVS and to refine the management of patients in terms of diagnosis, prevention, and treatment.
Document Type: Article de recherche
Issue Date: 8 April 2008
Open Access Date: Restricted access
Document version: VoR
Permalink: http://hdl.handle.net/20.500.11794/4208
This document was published in: Journal of the American College of Cardiology, Vol. 51 (14), 1327–1336 (2008)
http://dx.doi.org/10.1016/j.jacc.2007.12.031
Elsevier
Alternative version: 10.1016/j.jacc.2007.12.031
http://www.ncbi.nlm.nih.gov/pubmed/18387432
Collection:Articles publiés dans des revues avec comité de lecture

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