Transition-metal-free a-arylation of enolizable aryl ketones and mechanistic evidence for a radical process

Authors: Drapeau, Martin Pichette; Fabre, Indira; Grimaud, Laurence; Ciofini, Ilaria; Ollevier, Thierry; Taillefer, Marc
Abstract: The a-arylation of enolizable aryl ketones can be carried out with aryl halides under transition-metal-free conditions using KOtBu in DMF. The a-aryl ketones thus obtained can be used for step- and cost-economic syntheses of fused heterocycles and Tamoxifen. Mechanistic studies demonstrate the synergetic role of base and solvent for the initiation of the radical process.
Document Type: Article de recherche
Issue Date: 1 July 2015
Open Access Date: 16 March 2016
Document version: AM
Permalink: http://hdl.handle.net/20.500.11794/343
This document was published in: Angewandte Chemie International Edition, Vol. 54 (36), 10587–10591 (2015)
https://doi.org/10.1002/anie.201502332
John Wiley & Sons, Inc.
Alternative version: 10.1002/anie.201502332
Collection:Articles publiés dans des revues avec comité de lecture

Files in this item:
Description SizeFormat 
2015ACIE10587.pdf
Version of Record901.46 kBAdobe PDF    Request a copy
anie_201502332_sm_miscellaneous_information.pdf
Données supplémentaires3.07 MBAdobe PDF    Request a copy
Alpha-arylation ACIE versionacceptee.pdf659.36 kBAdobe PDFView/Open
All documents in CorpusUL are protected by Copyright Act of Canada.