GAD2 gene sequence variations are associated with eating behaviors and weight gain in women from the Quebec family study

Authors: Choquette, AnneLemieux, SimoneTremblay, AngeloDrapeau, VickyBouchard, ClaudeVohl, Marie-ClaudePérusse, Louis
Abstract: The glutamate decarboxylase 2 (GAD2) gene encodes for the glutamic acid decarboxylase enzyme (GAD65), which is implicated in the formation of the γ-aminobutyric acid (GABA), a neurotransmitter involved in the regulation of food intake. The objective of the present study was to test for association between GAD2 singlenucleotide polymorphisms (SNPs) and eating behaviors, dietary intake and obesity in subjects (n= 873) from the Quebec Family Study (QFS). Energy and macronutrient intakes were measured using a 3-day dietary record and eating behaviors were assessed using the Three-Factor Eating Questionnaire (TFEQ). Six SNPs capturing about 90% of GAD2 gene variability were genotyped and tested for association with age- and BMI- adjusted phenotypes. No evidence of association was found in men. In women, a SNP (rs992990; c.61450 C>A) was associated with disinhibition (p= 0.028), emotional susceptibility to disinhibition (p= 0.0005) and susceptibility to hunger (p= 0.028). Another SNP (rs7908975; c.8473A>C) was associated with carbohydrate (p= 0.021) and lipid (p= 0.021) intakes, disinhibition (p= 0.011) and two of its subscales (emotional and situational susceptibility) as well as with avoidance of fattening foods (p= 0.036). Six-year weight gain was two times higher in women carrying the variants associated with eating behaviors: 4.2 kg (vs 2.1 kg in non-carriers) in A-allele carriers of c.61450 C>A (p= 0.038) and 4.9 kg (vs 2.5 kg in noncarriers) in C-allele carriers of c. 8473 A>C (p= 0.013). The results suggest a role for the GAD2 gene in determining food intake, eating behaviors and weight gain over time in women.
Document Type: Article de recherche
Issue Date: 15 August 2009
Open Access Date: Restricted access
Document version: VoR
Permalink: http://hdl.handle.net/20.500.11794/15390
This document was published in: Physiology and Behaviours, Vol. 98 (4), 505–510 (2009)
https://doi.org/10.1016/j.physbeh.2009.08.004
Pergamon Press
Alternative version: 10.1016/j.physbeh.2009.08.004
19686769
Collection:Articles publiés dans des revues avec comité de lecture

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