In vivo models of cortical acquired epilepsy

Authors: Chauvette, SylvainSoltani, SaraSeigneur, JoséeTimofeev, Igor
Abstract: The neocortex is the site of origin of several forms of acquired epilepsy. Here we provide a brief review of experimental models that were recently developed to study neocortical epileptogenesis as well as some major results obtained with these methods. Most of neocortical seizures appear to be nocturnal and it is known that neuronal activities reveal high levels of synchrony during slow-wave sleep. Therefore, we start the review with a description of mechanisms of neuronal synchronization and major forms of synchronized normal and pathological activities. Then, we describe three experimental models of seizures and epileptogenesis: ketamine–xylazine anesthesia as feline seizure triggered factor, cortical undercut as cortical penetrating wound model and neocortical kindling. Besides specific technical details describing these models we also provide major features of pathological brain activities recorded during epileptogenesis and seizures. The most common feature of all models of neocortical epileptogenesis is the increased duration of network silent states that up-regulates neuronal excitability and eventually leads to epilepsy.
Document Type: Article de recherche
Issue Date: 3 September 2015
Open Access Date: Restricted access
Document version: VoR
Permalink: http://hdl.handle.net/20.500.11794/13955
This document was published in: Journal of Neuroscience Methods, Vol. 260, 185–201 (2016)
https://doi.org/10.1016/j.jneumeth.2015.08.030
Elsevier/North-Holland
Alternative version: 10.1016/j.jneumeth.2015.08.030
26343530
Collection:Articles publiés dans des revues avec comité de lecture

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