UGT genomic diversity : beyond gene duplication

Authors: Guillemette, ChantalLévesque, ÉricHarvey, MarioBellemare, JudithMénard, Vincent
Abstract: The human uridine diphospho (UDP)-glucuronosyltransferase (UGT) superfamily comprises enzymes responsible for a major biotransformation phase II pathway: the glucuronidation process. The UGT enzymes are located in the endoplasmic reticulum of almost all tissues, where they catalyze the inactivation of several endogenous and exogenous molecules, including bilirubin, sex steroids, numerous prescribed drugs, and environmental toxins. This metabolic pathway is particularly variable. The influence of inheritable polymorphisms in human UGT-encoding genes has been extensively documented and was shown to be responsible for a fraction of the observed phenotypic variability. Other key genomic processes are likely underlying this diversity; these include copy-number variations, epigenetic factors, and newly discovered splicing mechanisms. This review will discuss novel molecular aspects that may be determinant to UGT phenotypes.
Document Type: Article de recherche
Issue Date: 26 October 2009
Open Access Date: 28 September 2016
Document version: AM
Permalink: http://hdl.handle.net/20.500.11794/10528
This document was published in: Drug metabolism reviews, Vol. 42 (1), 24–44 (2010)
https://doi.org/10.3109/03602530903210682
Informa Healthcare
Alternative version: 10.3109/03602530903210682
19857043
Collection:Articles publiés dans des revues avec comité de lecture

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